{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:05Z","timestamp":1777694045554,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organs with different degrees of severity. SLE is typically diagnosed based on the presence of antinuclear antibodies (ANA) in the serum. However, seronegative SLE is rare and is diagnosed by clinicians when the patient\u2019s ANA is negative but fulfills other diagnostic criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>We report a case of a 15-year-old South Asian female with SLE who had negative antinuclear antibodies yet displayed the typical clinical presentations of photosensitive maculopapular rash, joint pain, alopecia, anemia, and thrombocytopenia. Clinical evaluations in conjunction with lab results were used to establish a diagnosis of ANA-negative SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ANA positivity is an entry criterion for SLE; rarely, cases of ANA-negative SLE may present. A typical clinical presentation may help determine the diagnosis in such a scenario. However, still, the physician should rule out immunodeficiency and other systemic illnesses before reaching a diagnosis of ANA-negative pediatric SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476231174321","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:16:28Z","timestamp":1684138588000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Dilemma of ANA-negative Pediatric Systemic Lupus Erythematosus in a South Asian Female"],"prefix":"10.1177","volume":"16","author":[{"given":"Qaisar Ali","family":"Khan","sequence":"first","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tehmina","family":"khan","sequence":"additional","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-3969","authenticated-orcid":false,"given":"Parsa","family":"Abdi","sequence":"additional","affiliation":[{"name":"Memorial University, St. Johns, Newfoundland, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Farkouh","sequence":"additional","affiliation":[{"name":"Rush Medical College, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Anthony","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza Amatul","family":"Hadi","sequence":"additional","affiliation":[{"name":"Mercer School of Medicine, Macon, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaira","family":"Iram","sequence":"additional","affiliation":[{"name":"Sultan Qaboos University, Muscat, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"bibr1-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1002\/art.23204"},{"key":"bibr2-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1002\/art.34472"},{"key":"bibr3-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644333"},{"key":"bibr4-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem335"},{"key":"bibr5-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0480-7"},{"key":"bibr6-11795476231174321","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2021.020502"},{"key":"bibr7-11795476231174321","unstructured":"Gomes RR, Khan SB. A young lady with ANA-negative SLE with secondary anti phospholipid syndrome. Open Journal of Orthopedics and Rheumatology. March 2,2023. https:\/\/www.peertechzpublications.com\/articles\/OJOR-5-126.php"},{"key":"bibr8-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-23488-0_13"},{"key":"bibr9-11795476231174321","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.20.0211"},{"key":"bibr10-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-018-0043-7"},{"key":"bibr11-11795476231174321","doi-asserted-by":"publisher","DOI":"10.3325\/CroatMedJ_60_0325"},{"key":"bibr12-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1540-0"},{"key":"bibr13-11795476231174321","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0198-0"},{"key":"bibr14-11795476231174321","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_189_20"},{"key":"bibr15-11795476231174321","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2009.24.1.76"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476231174321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476231174321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476231174321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:20Z","timestamp":1777454060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476231174321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":15,"alternative-id":["10.1177\/11795476231174321"],"URL":"https:\/\/doi.org\/10.1177\/11795476231174321","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"11795476231174321"}}