{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:46Z","timestamp":1777694086555,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Hirschsprung\u2019s disease is a congenital disorder characterized by the absence of nerve cells in the colon muscles, leading to difficulties in evacuating stool. This case report describes a newborn patient presenting with typical symptoms of the disease, including abdominal distension, constipation, diarrhea, and fever. The patient\u2019s initial laboratory investigations revealed anemia (Hb: 9.80\u2009g\/dL), low RBC count (3.50\u2009million\/cu mm), elevated RDW (16.70%), increased WBC count (11\u2009000\/cu mm), and raised platelet levels (891\u2009000\/\u00b5L) along with an elevated CRP (3.22). The baby received a comprehensive treatment regimen, including blood transfusion, Syp. MVBC, Enterogermina, Inj. Pan, Inj. Metro, Inj. Piptaz, Inj. Vancomycin, Calcium gluconate, and Inj. Aminoven. Following this treatment and necessary surgical intervention, the patient demonstrated significant improvement in frequent bowel movements and alleviation of other symptoms. This case highlights the importance of prompt diagnosis and multidisciplinary management for favorable outcomes in infants with Hirschsprung\u2019s disease.<\/jats:p>","DOI":"10.1177\/11795476241226577","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T06:11:26Z","timestamp":1705990286000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Detection and Intervention for Hirschsprung\u2019s Disease: A Key to Successful Outcomes"],"prefix":"10.1177","volume":"17","author":[{"given":"Karishma","family":"Rathi","sequence":"first","affiliation":[{"name":"Assistant Professor of the Department of Pharmacy Practice at Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aanya","family":"Verma","sequence":"additional","affiliation":[{"name":"Pharm D Intern, Department of Pharmacy Practice at Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Pingat","sequence":"additional","affiliation":[{"name":"Pharm D Intern, Department of Pharmacy Practice at Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"bibr1-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2008.07.005"},{"key":"bibr2-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1177\/0009922813500846"},{"key":"bibr3-11795476241226577","first-page":"568","volume":"46","author":"Badner JA","year":"1990","journal-title":"Am J Hum Genet"},{"key":"bibr4-11795476241226577","volume-title":"Hirschsprung\u2019s Disease and Allied Disorders","author":"Holschneider AM","year":"2000","edition":"2"},{"key":"bibr5-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1542\/peds.38.2.185"},{"key":"bibr6-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.07.007"},{"key":"bibr7-11795476241226577","first-page":"1319","volume":"74","author":"Kessmann J.","year":"2006","journal-title":"Am Fam Physician"},{"key":"bibr8-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.149"},{"key":"bibr9-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619892351"},{"key":"bibr10-11795476241226577","unstructured":"Mayo Clinic. Hirschsprung\u2019s disease - Diagnosis and treatment - Mayo Clinic. www.mayoclinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/hirschsprungs-disease\/diagnosis-treatment\/drc-20351561."},{"key":"bibr11-11795476241226577","first-page":"3:196","author":"Santos J","year":"2002","journal-title":"Rev Bras Coloproctol"},{"key":"bibr12-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311872"},{"key":"bibr13-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1590\/0102-6720201600030007"},{"key":"bibr14-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3632-5"},{"key":"bibr15-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2013.04.004"},{"key":"bibr16-11795476241226577","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2013.030"},{"key":"bibr17-11795476241226577","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01362-3"},{"key":"bibr18-11795476241226577","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.182562"},{"key":"bibr19-11795476241226577","unstructured":"Prakash M. Hirschsprung\u2019s disease scientific update: Sultan Qaboos University Hospital. Sultan Qaboos Univ Med J. 2011;11:138-145. 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