{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:55:51Z","timestamp":1777694151663,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Paeniclostridium sordellii, a spore-forming anaerobic Gram-positive rod commonly found in soil samples, is rarely associated with human disease. The authors report a rare case of P. sordelli osteomyelitis of the left distal femur in a young male patient, which is the first reported case of P. sordelli from Pakistan. A 21-year-old male, laborer by profession, presented with low-grade fever, fatigue and lethargy since more than a month, which progressed in severity over the last 2\u2009weeks. On CT scan, abnormal thickening of the cortical bone along with encroachment of the medullary cavity was observed in the left distal femur. A diagnosis of acute osteomyelitis was made and surgical intervention was performed to remove infected bone and soft tissue, which were sent for culture to the Microbiology laboratory. Bone and soft tissue cultures yielded no growth after 72\u2009hours of aerobic incubation. However, bacterial growth was observed after anaerobic incubation, in bone culture, which was identified as P. sordellii using Vitek\n                    <jats:sup>\u00ae<\/jats:sup>\n                    2 automated system. Penicillin, piperacillin-tazobactam, meropenem, vancomycin and metronidazole were susceptible whereas, clindamycin was resistant in the isolate. The patient was started on metronidazole and after he remained stable with a clean surgical wound and symptomatic management, was discharged on regular follow-up as an out-patient. Since, P. sordelli is rare and highly fatal in most cases, prompt reporting and insights from treated infections could pave the way for successful management.\n                  <\/jats:p>","DOI":"10.1177\/11795476241275440","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:03:45Z","timestamp":1724288625000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Ordinary: Paeniclostridium sordellii Osteomyelitis in a Young Male Patient From Pakistan"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2726-277X","authenticated-orcid":false,"given":"Moiz Ahmed","family":"Khan","sequence":"first","affiliation":[{"name":"Section of Microbiology, Department of Pathology, Indus Hospital and Health Network, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Samiya","family":"Kamal","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Pathology, Indus Hospital and Health Network, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Summaiya","family":"Zafar","sequence":"additional","affiliation":[{"name":"Section of Histopathology, Department of Pathology and Lab Medicine, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"bibr1-11795476241275440","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s15010-008-8192-y","volume":"37","author":"Matten J","year":"2009","journal-title":"Infection"},{"key":"bibr2-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1086\/508866"},{"key":"bibr3-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2014.09.003"},{"key":"bibr4-11795476241275440","volume":"38","author":"Kimura AC","year":"2004","journal-title":"Clin Infect Dis"},{"key":"bibr5-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-007-0163-9"},{"key":"bibr6-11795476241275440","unstructured":"ESCMID-European Society of Clinical Microbiology. Infectious diseases. EUCAST: clinical breakpoints and dosing of antibiotics. Eucast.org. 2024. Accessed July 1, 2024. https:\/\/www.eucast.org\/clinical_breakpoints"},{"key":"bibr7-11795476241275440","unstructured":"Clinical & Laboratory Standards Institute M100 Ed34. 2024. Accessed July\u20091, 2024. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/"},{"key":"bibr8-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.08.009"},{"key":"bibr9-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03414-14"},{"key":"bibr10-11795476241275440","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.06.009"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476241275440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476241275440","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476241275440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:33Z","timestamp":1777454073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476241275440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":10,"alternative-id":["10.1177\/11795476241275440"],"URL":"https:\/\/doi.org\/10.1177\/11795476241275440","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"11795476241275440"}}