{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:53:36Z","timestamp":1787320416203,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Drug-induced acute pancreatitis is a rare condition occurs at an incidence rate of 0.1\u20131.4% and represents a diagnostic challenge. TNF\u03b1 inhibitors specially adalimumab is very rarely reported in the literature, primarily through case reports, as a potential cause of acute pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>Our case report presents a case of a 23-year-old patient followed for Crohn disease in whom a diagnosis of acute pancreatitis induced by adalimumab was made. This diagnosis was confirmed after the elimination of other possible etiologies, and notably by the recurrence of pancreatitis after Adalimumab rechallenge. The occurrence of acute pancreatitis induced by TNF\u03b1 inhibitors exposes to the risk of pancreatitis with other drugs in this class, hence the need to switch to another therapeutic class, which was Ustekinumab in our case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acute pancreatitis is an unusual complication of treatment with Adalimumab. Through our experience, based on solid scientific data, we want to draw the attention of clinicians to the reality of this complication. It should be considered in any patient on TNF\u03b1 inhibitors who presents with acute pancreatitis without an obvious cause.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476251315000","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:08:02Z","timestamp":1737529682000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn\u2019s Disease Patient"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-7534","authenticated-orcid":false,"given":"Walid","family":"El Ouardi","sequence":"first","affiliation":[{"name":"Resident in Gastroenterology, Faculty of Medicine and Pharmacy, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Benazzouz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, International University of Rabat\/Riad Annakhil International Polyclinic, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"bibr1-11795476251315000","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.405"},{"issue":"1","key":"bibr2-11795476251315000","first-page":"45","volume":"15","author":"Jones MR","year":"2015","journal-title":"Ochsner J"},{"key":"bibr3-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01485.x"},{"key":"bibr4-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001428"},{"key":"bibr5-11795476251315000","doi-asserted-by":"crossref","unstructured":"Jevtic D, Dumic I, Nordin T, et al. Less known gastrointestinal manifestations of drug reaction with eosinophilia and systemic symptoms ( DRESS ) syndrome: a systematic review of the literature. Published online 2021.","DOI":"10.3390\/jcm10184287"},{"key":"bibr6-11795476251315000","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002645"},{"key":"bibr7-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221115312"},{"key":"bibr8-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.05.008"},{"key":"bibr9-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182142fd2"},{"key":"bibr10-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1159\/000327708"},{"key":"bibr11-11795476251315000","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i16.2080"},{"key":"bibr12-11795476251315000","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i44.16559"},{"key":"bibr13-11795476251315000","first-page":"1","volume":"13","author":"Saini J","year":"2023","journal-title":"Clin Translat Gastroenterol"},{"key":"bibr14-11795476251315000","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.103"},{"key":"bibr15-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1007\/s41971-019-00061-6"},{"key":"bibr16-11795476251315000","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcz267"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251315000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476251315000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251315000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:37Z","timestamp":1777454077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476251315000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"alternative-id":["10.1177\/11795476251315000"],"URL":"https:\/\/doi.org\/10.1177\/11795476251315000","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"11795476251315000"}}