{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:20Z","timestamp":1777694240766,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lumbar interbody fusion (LIF) is a widely used surgical technique for treating degenerative spinal conditions. However, challenges such as pseudarthrosis and implant migration remain significant concerns. This case report presents the use of a novel trabecular titanium cage combined with a biocomposite hydrogel containing stromal-vascular fraction and BMP-2 to enhance osseointegration and accelerate bone fusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 61-year-old female patient with severe chronic lumbar pain, functional impairment, and grade II anterolisthesis of L4 underwent lumbar interbody fusion. A custom-designed trabecular titanium cage was implanted, featuring an optimized porous structure for enhanced fixation and bone ingrowth. To further promote bone regeneration, a biocomposite hydrogel synthesized from adipose-derived stromal-vascular fraction and BMP-2 was applied. Postoperative assessment demonstrated significant pain reduction, improved functional activity, and early bone fusion formation. Radiological imaging confirmed stable implant positioning, progressive trabecularization, and successful osseointegration. No complications, such as implant migration or material loosening, were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This case highlights the potential benefits of combining advanced implant design with bioactive materials in spinal fusion surgery. The approach resulted in early and stable bone integration, reduced pain, and improved functional recovery. Further studies with larger patient cohorts and extended follow-up periods are needed to validate these findings and assess long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476251357427","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T04:34:37Z","timestamp":1755318877000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of Biocomposite Hydrogel With Developed Trabecular Cage in Lumbar Interbody Fusion: A Clinical Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"Murat U.","family":"Baidarbekov","sequence":"first","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olzhas S.","family":"Bekarisov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7188-1369","authenticated-orcid":false,"given":"Zhangir N.","family":"Ipmagambetov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan"},{"name":"Medical University of Karaganda, Karaganda, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margulan S.","family":"Abdigalikov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agzam A.","family":"Akimbekov","sequence":"additional","affiliation":[{"name":"Medical University of Karaganda, Karaganda, Kazakhstan"},{"name":"National Research Oncology Center, Astana, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-018-03670-w"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/os.12264"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-07531-w"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.14444\/8057"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073638"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2023.2197503"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.11.001"},{"issue":"10","key":"e_1_3_2_9_2","article-title":"Safety and tolerability of stromal vascular fraction combined with \u03b2-tricalcium phosphate in posterior lumbar interbody fusion: phase I clinical trial","volume":"9","author":"Choi UY","year":"2020","unstructured":"Choi UY, Kim KT, Kim KG, et al Safety and tolerability of stromal vascular fraction combined with \u03b2-tricalcium phosphate in posterior lumbar interbody fusion: phase I clinical trial. Cells. 2020;9(10):2250.","journal-title":"Cells"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym14245343"},{"key":"e_1_3_2_11_2","first-page":"371","article-title":"Spondylolisthesis","volume":"54","author":"Meyerding HW","year":"1932","unstructured":"Meyerding HW. Spondylolisthesis. Surg Gynecol Obstet. 1932;54:371-377.","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336678"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"e_1_3_2_14_2","first-page":"29","article-title":"A method for obtaining an injectable biocomposite hydrogel to stimulate the regeneration of bone and cartilage tissue","volume":"33784","author":"Ogay VB","year":"2019","unstructured":"Ogay VB, Isabekova AS, Sarsenova MA, Ramankulov EM. A method for obtaining an injectable biocomposite hydrogel to stimulate the regeneration of bone and cartilage tissue. Patent of the Republic of Kazakhstan. 2019;33784:29.","journal-title":"Patent of the Republic of Kazakhstan"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520920090"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.14444\/8640"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wnsx.2025.100440"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.06.062"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-019-09737-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052379"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.14245\/ns.2040058.029"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.07.195"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/2192568217701102"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11050437"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251357427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476251357427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251357427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:43Z","timestamp":1777454083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476251357427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":23,"alternative-id":["10.1177\/11795476251357427"],"URL":"https:\/\/doi.org\/10.1177\/11795476251357427","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"11795476251357427"}}