{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:26:29Z","timestamp":1778228789682,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Methemoglobinemia is a rare but potentially life-threatening condition characterized by the oxidation of hemoglobin iron from ferrous (Fe\u00b2\u207a) to ferric (Fe\u00b3\u207a) state, impairing its oxygen-carrying capacity. Acquired forms can be triggered by exposure to oxidizing agents, such as nitrobenzene. We present the case of a 32-year-old female who developed symptomatic methemoglobinemia following oral ingestion of a commercial stimulant product containing nitrobenzene. She presented with peripheral cyanosis, breathlessness, and hypoxia unresponsive to oxygen therapy. A diagnosis of methemoglobinemia was confirmed, and prompt administration of intravenous methylene blue led to rapid clinical improvement. This case emphasizes the importance of early recognition of acquired methemoglobinemia in the context of toxic exposure, especially when conventional respiratory or cardiac pathology is excluded. Methylene blue remains the first-line antidote, offering effective and timely reversal of symptoms.<\/jats:p>","DOI":"10.1177\/11795476251370548","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T07:59:15Z","timestamp":1756108755000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Acquired Methemoglobinemia Following Nitrobenzene Poisoning: An Unusual Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"Venkata Sarma Jayant","family":"Tetta","sequence":"first","affiliation":[{"name":"Government Medical College (GMC), Srikakulam, Andhra Pradesh, India"},{"name":"Squad Medicine and Research (SMR), Amadalavalasa, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun Kumar","family":"Suvvari","sequence":"additional","affiliation":[{"name":"Squad Medicine and Research (SMR), Amadalavalasa, Andhra Pradesh, India"},{"name":"Rangaraya Medical College, Kakinada, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmitha Reddy","family":"Sagili","sequence":"additional","affiliation":[{"name":"JSS Medical College, Mysuru, Karnataka, India"},{"name":"Royal Stoke University Hospital, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3869-290X","authenticated-orcid":false,"given":"Srinivasa Rajasekhar","family":"Kata","sequence":"additional","affiliation":[{"name":"Katuri Medical College &amp; Hospital, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindhuja","family":"Karangula","sequence":"additional","affiliation":[{"name":"Malla Reddy Institute of Medical Sciences (MRIMS), Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Odessa National Medical University, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3334-9191","authenticated-orcid":false,"given":"Vimal","family":"Thomas","sequence":"additional","affiliation":[{"name":"Squad Medicine and Research (SMR), Amadalavalasa, Andhra Pradesh, India"},{"name":"Tbilisi State Medical University, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20738"},{"key":"e_1_3_3_3_2","first-page":"93","article-title":"Methemoglobinemia - a case report and literature review","volume":"61","author":"Ivek I","year":"2022","unstructured":"Ivek I, Knotek T, Ivi\u010di\u0107 T, Rubini\u0107 B, Bajlo P, Hamzi\u0107 J. Methemoglobinemia - a case report and literature review. Acta Clin Croat. 2022;61(Suppl 1):93-98.","journal-title":"Acta Clin Croat"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e318232139f"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.90112"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(99)70167-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000141096.00377.3f"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/11597790-000000000-00000"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002526"},{"issue":"6","key":"e_1_3_3_10_2","first-page":"416","article-title":"Occupational methaemoglobinaemia","volume":"53","author":"Bradberry SM.","year":"2003","unstructured":"Bradberry SM. Occupational methaemoglobinaemia. Occup Med. 2003;53(6):416-419.","journal-title":"Occup Med"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251370548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476251370548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251370548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:44Z","timestamp":1777454084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476251370548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":9,"alternative-id":["10.1177\/11795476251370548"],"URL":"https:\/\/doi.org\/10.1177\/11795476251370548","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"11795476251370548"}}