{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:32Z","timestamp":1777694252239,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hypokalemic periodic paralysis (HPP) is a severe yet reversible neuromuscular condition precipitated by profound hypokalemia. Autoimmune disorders can exacerbate renal potassium loss resulting in abrupt muscle weakness. Primary Sj\u00f6gren\u2019s syndrome (pSS), an autoimmune disease characterized by exocrine gland insufficiency, can lead to renal tubular dysfunction and episodes of HPP when distal acidification is compromised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 40-year-old woman was admitted with rapidly progressive, painless quadriplegia for over 2\u2009days. Laboratory tests revealed critical hypokalemia (1.4\u2009mEq\/L), metabolic acidosis, and alkaline urine pH, which was consistent with type 1 distal renal tubular acidosis (dRTA). Serologic studies confirmed pSS. Corrective measures included intravenous potassium chloride and sodium bicarbonate along with immunomodulation with intravenous methylprednisolone, followed by oral prednisolone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The patient\u2019s presentation illustrates how autoimmune-mediated renal tubular dysfunction can precipitate HPP. Failure of distal acid excretion impairs potassium handling, amplifying the risk of potentially life-threatening neuromuscular collapse. Stabilization requires meticulous electrolyte repletion and treatment of the underlying autoimmunity. Restoration of serum potassium levels, acid-base balance, and targeted immunosuppression resulted in rapid clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An accurate diagnosis of HPP secondary to dRTA and Sj\u00f6gren\u2019s syndrome requires high clinical suspicion. Prompt recognition and intervention, including immunotherapy and balanced electrolyte replacement, can prevent profound neuromuscular complications and improve patient outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476251372407","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T04:09:47Z","timestamp":1756613387000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypokalemic Periodic Paralysis in a Patient With Primary Sj\u00f6gren\u2019s Syndrome and Distal Renal Tubular Acidosis: A Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"Vansh","family":"Varma","sequence":"first","affiliation":[{"name":"GMERS Medical College and Hospital, Valsad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Kumar","family":"Patel","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital, Valsad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitya","family":"Pathak","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital, Gotri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Patel","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital, Valsad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Kumar","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Gaidhane","sequence":"additional","affiliation":[{"name":"One Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Dr. D. 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Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, India"},{"name":"Department of Medicine, Korea University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakasini","family":"Satapathy","sequence":"additional","affiliation":[{"name":"University Center for Research and Development, Chandigarh University, Mohali, Punjab, India"},{"name":"Medical Laboratories Techniques Department, AL-Mustaqbal University, Hillah, Babil, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Mehta","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-4874","authenticated-orcid":false,"given":"Amogh","family":"Verma","sequence":"additional","affiliation":[{"name":"SR Sanjeevani Hospital, Kalyanpur, Siraha, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000541585"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4529009"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/mjhs.mjhs_79_24"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2023.08.006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-023-00375-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14483"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.260123.ina"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-024-00333-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11964-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27695"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1724114"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35841"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2024.0290"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03318-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.36106\/ijar\/0103081"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.15562\/bmj.v12i3.5195"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.8266"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7769"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.36347\/sjmcr.2024.v12i11.030"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.384195"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.903476"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew376"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01619-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.69849\/revistaft\/ar10202411022251"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcae175.355"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-03189-8"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251372407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476251372407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251372407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:45Z","timestamp":1777454085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476251372407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":27,"alternative-id":["10.1177\/11795476251372407"],"URL":"https:\/\/doi.org\/10.1177\/11795476251372407","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"11795476251372407"}}