{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:33Z","timestamp":1777694253802,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This report presents a unique case of subacute BCS in a patient with systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and multiple inherited thrombophilic disorders No previous history and lack of inciting events meant extensive investigation had to be done to figure out the underlying pathology. The amalgam of thrombophilias presenting initially as Sub-Acute Budd Chiari syndrome is very rare to find in the literature and highlights the importance of early screening and diagnosis to prevent complications of Thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>The patient presented with a 3\u2009months history of progressive abdominal distension, hematemesis, and altered consciousness. The diagnosis made was Sub-Acute Budd Chiari Syndrome. The patient was managed with anticoagulation, diuretics, and symptomatic treatment. After stabilization the patient was discharged for follow-up after 2\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Key Take-Away Lessons:<\/jats:title>\n                    <jats:p>This case highlights the diagnostic challenges of BCS, particularly in patients with hereditary hypercoagulability. Early recognition and management are critical in preventing severe complications of thrombosis. Moreover, it underscores the impact of limited healthcare access in rural settings, emphasizing the need for improved screening, awareness, and targeted interventions for thrombophilic disorders with a set diagnostic criteria for sub-acute presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476251377952","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T05:55:56Z","timestamp":1758174956000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Triple Threat: SLE, APS, and Clotting Factor Abnormalities Leading to Subacute Budd-Chiari Syndrome. A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"18","author":[{"given":"Khadija","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Medicine, Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2328-1148","authenticated-orcid":false,"given":"Areeb","family":"Jawed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4557-5743","authenticated-orcid":false,"given":"Muddassir Syed","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Medicine, KMDC\/Abbasi Shaheed Hospital, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6755-1927","authenticated-orcid":false,"given":"Nidal","family":"Bin Kamran","sequence":"additional","affiliation":[{"name":"Department of Medicine, KMDC\/Abbasi Shaheed Hospital, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laiba","family":"Shahbaz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i19.2693"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.10.014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.1996.11.1.82"},{"key":"e_1_3_3_5_2","unstructured":"CARE Checklist\u2014CARE Case Report Guidelines [Internet]. 2013. Accessed March 1 2025. https:\/\/www.care-statement.org\/checklist"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9232-1_2"},{"issue":"5","key":"e_1_3_3_7_2","first-page":"301","article-title":"Clinical characteristics and outcome of Budd-Chiari syndrome at a tertiary care hospital in Pakistan","volume":"27","author":"Parkash O","year":"2017","unstructured":"Parkash O, Khan A, Hamid S. Clinical characteristics and outcome of Budd-Chiari syndrome at a tertiary care hospital in Pakistan. J Coll Physicians Surg Pak. 2017;27(5):301-304.","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10189-4"},{"key":"e_1_3_3_9_2","first-page":"1","volume-title":"Budd-Chiari Syndrome","author":"Hitawala AA","year":"2025","unstructured":"Hitawala AA, Goosenberg E. Budd-Chiari syndrome. In: Budd-Chiari Syndrome. 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