{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:58Z","timestamp":1777694278248,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016834","name":"Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["2024WSJK022"],"award-info":[{"award-number":["2024WSJK022"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Aconitine, a highly toxic diterpenoid alkaloid derived from the\n                      <jats:italic toggle=\"yes\">Aconitum<\/jats:italic>\n                      genus, continues to be utilized in traditional Chinese medicine. Aconitine poisoning is common in China and often causes malignant arrhythmias and cardiac arrest, with a mortality rate of approximately 15.1%. Using venous-arterial extracorporeal membrane oxygenation (VA-ECMO) in this context has been rarely reported, and associated microcirculatory changes have not been described.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>\n                      We present a case of a 59-year-old man who ingested a topical medicinal wine prepared from\n                      <jats:italic toggle=\"yes\">Aconitum brachypodum<\/jats:italic>\n                      Diels. Despite the conventional treatment administered, the patient developed a cardiac arrest 2\u2009hours after admission. VA-ECMO was promptly initiated alongside repeated cardiopulmonary resuscitation and electrical defibrillation. After 6\u2009hours of VA-ECMO initiation, the heart rhythm of the patient stabilized to sinus without further malignant arrhythmias. Microcirculatory monitoring was performed using sublingual microcirculation during VA-ECMO support, which was used for a total of 46\u2009hours. The patient was transferred out of the intensive care unit (ICU) after 7\u2009days of hospitalization and was eventually discharged without any sequelae.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early initiation of VA-ECMO support may help stabilize cardiac electrical storms in patients with aconitine poisoning. Sublingual microcirculation monitoring may play a role in predicting VA-ECMO weaning success and patient but this requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476251397165","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:38:41Z","timestamp":1764070721000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Microcirculatory Changes in a Venous-Arterial Extracorporeal Membrane Oxygenation-Supported Patient with Cardiac Arrest Due to Aconitine Poisoning: A Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Intensive Care Unit, People\u2019s Hospital of Chongqing Liangjiang New Area, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, People\u2019s Hospital of Chongqing Liangjiang New Area, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Ma","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, People\u2019s Hospital of Chongqing Liangjiang New Area, China"},{"name":"The First Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3407-751X","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, People\u2019s Hospital of Chongqing Liangjiang New Area, China"},{"name":"The First Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.11.005"},{"issue":"5","key":"e_1_3_3_3_2","first-page":"580","article-title":"Epidemiological analysis of plant food poisoning events in China from 2004 to 2013","volume":"28","author":"Wang R","year":"2016","unstructured":"Wang R, Ding W, Gao YJ, Wang XY, Li Q. Epidemiological analysis of plant food poisoning events in China from 2004 to 2013. Chin J Food Hyg. 2016;28(5):580-584.","journal-title":"Chin J Food Hyg"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2021.09.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1764160"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004072"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154090"},{"issue":"2","key":"e_1_3_3_8_2","first-page":"40","article-title":"Clinical analysis of 56 cases of arrhythmia induced by aconitine poisoning","volume":"22","author":"Li JQ.","year":"2016","unstructured":"Li JQ. Clinical analysis of 56 cases of arrhythmia induced by aconitine poisoning. Contemp Med. 2016;22(2):40-41.","journal-title":"Contemp Med"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2024.110487"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591241280163"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.70047"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202208-1523ED"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01130-z"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.70051"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001937"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1519-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1855-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5070-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14754"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251397165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476251397165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476251397165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:48Z","timestamp":1777454088000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476251397165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":18,"alternative-id":["10.1177\/11795476251397165"],"URL":"https:\/\/doi.org\/10.1177\/11795476251397165","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"11795476251397165"}}