{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:55:41Z","timestamp":1777694141209,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Endoscopic ultrasound-guided transoesophageal biopsy (EUS-FNA\/FNB) is a minimally invasive and highly accurate diagnostic technique for evaluating mediastinal lesions, particularly in centres where surgical approaches or endobronchial ultrasound are unavailable. We report the case of a 79-year-old woman with multiple comorbidities who presented with non-specific abdominal pain and a 5\u2009kg weight loss over 1\u2009month. Imaging revealed a 50% left pleural effusion and mediastinal and retroperitoneal lymphadenopathy. Endoscopic ultrasound demonstrated hilar, retroperitoneal and interaortocaval lymph nodes, prompting a transoesophageal fine-needle biopsy using a 22G needle and fanning technique, which was performed without complications. Initial histopathology suggested a lymphoproliferative process, and a subsequent excisional lymph node biopsy confirmed classical mixed-cellularity Hodgkin lymphoma associated with Epstein\u2013Barr virus. This case highlights the diagnostic value of EUS-FNA\/FNB in mediastinal lesions that are difficult to access using traditional techniques. Although its diagnostic yield is high, lymphomas\u2014particularly Hodgkin lymphoma\u2014may require additional tissue sampling to preserve architectural detail. Procedure success depends on sample adequacy, needle selection and operator expertise. Integrating EUS-guided biopsy into a multidisciplinary diagnostic pathway enables safe, effective and timely evaluation of mediastinal pathology, especially in resource-limited settings or in patients with significant comorbidities.<\/jats:p>","DOI":"10.1177\/11795476261440723","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:52:17Z","timestamp":1777110737000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Ultrasound-Guided Transoesophageal Biopsy in a Mediastinal Tumour: A Case Report"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3484-1691","authenticated-orcid":false,"given":"Roberto Antonio","family":"Alvarado-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Surgery and Gastrointestinal Endoscopy, UNAM, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-8633","authenticated-orcid":false,"given":"Yoeli Marisa","family":"Escand\u00f3n-Espinoza","sequence":"additional","affiliation":[{"name":"Department of Surgery and Gastrointestinal Endoscopy, UNAM, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0216-2372","authenticated-orcid":false,"given":"Katia Daniela","family":"L\u00f3pez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Surgery and Gastrointestinal Endoscopy, UNAM, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-025-00409-w"},{"key":"e_1_3_3_3_2","article-title":"Outcome of endoscopic ultrasound-guided sampling of mediastinal lymphadenopathy","volume":"2022","author":"Park TY","unstructured":"Park TY, Moon JS. Outcome of endoscopic ultrasound-guided sampling of mediastinal lymphadenopathy. Gastroenterol Res Pract. 2022;2022:4486241-4486247.","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1362"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/med-20-51"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31821d41c8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000475843"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_138_19"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1965"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.089"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15030349"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-119219"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3028"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2353"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00064515"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000900013"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1705"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2397430"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2355"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476261440723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476261440723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476261440723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:32Z","timestamp":1777454072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476261440723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":19,"alternative-id":["10.1177\/11795476261440723"],"URL":"https:\/\/doi.org\/10.1177\/11795476261440723","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"11795476261440723"}}