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The prevalence has been found to increase with age, with some ultrasonographic studies showing a prevalence as high as 25% of adults with knee pain. We discuss an interesting case of a 14-year- old male with a ruptured cyst found to be secondary to Lyme disease. The patient was treated with clindamycin and his symptoms had resolved. We discuss cases of ruptured baker\u2019s cysts in the literature found to be secondary to Lyme disease with their respective treatments and outcomes.<\/jats:p>","DOI":"10.1177\/11795476261457180","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T10:23:41Z","timestamp":1780223021000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lyme Disease Presenting as Rupture Baker\u2019s Cyst: Case Report and Literature Review"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-6532","authenticated-orcid":false,"given":"Abdullah","family":"Ghali","sequence":"first","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Mody-Bailey","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Jabin","sequence":"additional","affiliation":[{"name":"Texas A&M School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Abdou","sequence":"additional","affiliation":[{"name":"Kings County Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momin","family":"Hussain","sequence":"additional","affiliation":[{"name":"UT Health San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"Maimonides Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"177","article-title":"Popliteal (Baker\u2019s) Cysts in the Setting of Primary Knee Arthroplasty","volume":"37","author":"Tofte JN","year":"2017","unstructured":"Tofte JN, Holte AJ, Noiseux N. Popliteal (Baker\u2019s) Cysts in the Setting of Primary Knee Arthroplasty. Iowa Orthop J. 2017;37:177-180.","journal-title":"Iowa Orthop J"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2013.715"},{"key":"e_1_3_5_4_2","unstructured":"Leib AD Roshan A Foris LA Varacallo M. Baker\u2019s Cyst. In: StatPearls [Internet]. 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