{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:58:17Z","timestamp":1777532297873,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Circ Respir Pulm Med"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Paraneoplastic hyper-eosinophilia associated with metastatic lung adenocarcinoma is a rare finding and has been associated with a poor prognosis when present. Early hyper-eosinophilia appearing following non-small cell lung cancer (NSCLC) treatment with immune checkpoint inhibitors (ICI) has been previously reported with contradictory outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary:<\/jats:title>\n                    <jats:p>We present the case of an elderly man with newly diagnosed metastatic lung adenocarcinoma and baseline hyper-eosinophilia, treated with pembrolizumab, and showing evidence of significant and rapid disease progression suggestive of hyper-progressive disease, worsening baseline hyper-eosinophilia, and a fatal outcome within 1\u2009month of therapy initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pre-treatment hyper-eosinophilia could represent a predictive factor of an unfavorable response to ICI treatment in cases of NSCLC. Additional similar cases are needed to draw a more conclusive relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795484211030164","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T13:39:11Z","timestamp":1627738751000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab"],"prefix":"10.1177","volume":"15","author":[{"given":"Hisham","family":"Wehbe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kozah","sequence":"additional","affiliation":[{"name":"Division of Infectious diseases, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-9267","authenticated-orcid":false,"given":"Salwa A","family":"Koubaissi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"bibr1-11795484211030164","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0128"},{"key":"bibr2-11795484211030164","first-page":"e2866","volume":"10","author":"Abughanimeh O","year":"2018","journal-title":"Cureus"},{"key":"bibr3-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrc.2015.05.002"},{"key":"bibr4-11795484211030164","doi-asserted-by":"publisher","DOI":"10.7196\/SARJ.2015.v21i4.38"},{"key":"bibr5-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"bibr6-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-018-0078-z"},{"key":"bibr7-11795484211030164","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2019-0183"},{"key":"bibr8-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.8899"},{"key":"bibr9-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2412"},{"key":"bibr10-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.011"},{"key":"bibr11-11795484211030164","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3159"}],"container-title":["Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795484211030164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795484211030164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795484211030164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:48:01Z","timestamp":1777394881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795484211030164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"alternative-id":["10.1177\/11795484211030164"],"URL":"https:\/\/doi.org\/10.1177\/11795484211030164","relation":{},"ISSN":["1179-5484","1179-5484"],"issn-type":[{"value":"1179-5484","type":"print"},{"value":"1179-5484","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"11795484211030164"}}