{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:52:49Z","timestamp":1783745569358,"version":"3.55.0"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Patients with primary hyperparathyroidism (PHPT) experience bone mineral density (BMD) loss and trabecular bone score (TBS) alteration, which current guidelines recommend assessing. Considering TBS alongside BMD for a 10-year fracture risk assessment (FRAX) may improve PHPT management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Retrospective, cross-sectional study composed of 49 Caucasian females (62\u2009\u00b1\u200910.6\u2009years, 27.7\u2009\u00b1\u20090.87\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) with PHPT and 132 matched control subjects (61.3\u2009\u00b1\u200910.5\u2009years, 27.5\u2009\u00b1\u20090.49\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) evaluated in 3\u2009years. We assessed lumbar spine (LS) and femoral neck (FN) BMD, T and Z scores (GE Healthcare Lunar Osteodensitometer) and TBS (iNsight 1.8), major osteoporotic fracture (MOF), and hip FRAX.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients with PHPT had statistically lower mean values for lumbar spine bone mineral density (LS BMD) (0.95\u2009\u00b1\u20090.25 vs 1.01\u2009\u00b1\u20090.14\u2009g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , P\u2009=\u2009.01), LS T-scores (\u22122\u2009\u00b1\u20090.2 vs \u22121.4\u2009\u00b1\u20090.1 SD, P\u2009=\u2009.009), LS Z scores (\u22120.9\u2009\u00b1\u20090.19 vs \u22120.1\u2009\u00b1\u20090.11 SD, P\u2009=\u2009.009), femoral neck bone mineral density (FN BMD) (0.79\u2009\u00b1\u20090.02 vs 0.83\u2009\u00b1\u20090.01\u2009g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , P\u2009=\u2009.02), FN T-scores (\u22121.8\u2009\u00b1\u20090.13 vs \u22121.5\u2009\u00b1\u20090.07 SD, P\u2009=\u2009.017), FN Z scores (\u22120.51\u2009\u00b1\u20090.87 vs \u22120.1\u2009\u00b1\u20090.82 SD, P\u2009=\u2009.006), and TBS (0.95\u2009\u00b1\u20090.25 vs 1.01\u2009\u00b1\u20090.14\u2009g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , P\u2009=\u2009.01) compared with control subjects. 22.4% of patients with PHPT had degraded microarchitecture (TBS\u2009&lt;\u20091.2) vs. 7.6% in control group (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.008). PHPT proved to be a covariate with unique contribution ( P\u2009=\u2009.031) alongside LS BMD ( P\u2009=\u2009.040) in a linear regression model [ R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.532, F(4,16)\u2009=\u20094.543] for TBS\u2009&lt;\u20091.2. TBS adjustment elevated MOF FRAX both for PHPT (4.35\u2009\u2009\u00b1\u20090.6% vs 5.25%\u2009\u00b1\u20090.73%, P\u2009&lt;\u2009.001) and control groups (4.5\u2009\u2009\u00b1\u20090.24% vs 4.7%\u2009\u00b1\u20090.26%, P\u2009&lt;\u2009.001) compared with BMD-bases FRAX, but also increased differently between the 2 study groups (1.1-folds for PHPT patients and 1.04 for control subjects, P\u2009=\u2009.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared with control, TBS-adjusted FRAX provides significantly higher MOF risk than BMD-based FRAX in PHPT women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795514221145840","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:46:16Z","timestamp":1674261976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Degraded Bone Microarchitecture in Women with PHPT\u2013Significant Predictor of Fracture Probability"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-7164","authenticated-orcid":false,"given":"Theodor Eugen","family":"Oprea","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania"},{"name":"Municipal Hospital, Oltenita, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Gabriela","family":"Barbu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Medicine and Pharmacy Carol Davila, Bucharest, 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