{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:57:05Z","timestamp":1785869825956,"version":"3.56.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>(1) Describe the clinical spectrum, imaging features, management, and outcome of brown tumors (BT) of the jaws. (2) Determine via a literature review the facts and controversies around the characteristics and management of this lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Our study was approved by the institutional committee of Sahloul University Hospital in accordance with the ethical standards of the Declaration of Helsinki. Sixteen patients with BT in the context of a primary, secondary, and tertiary hyperparathyroidism were treated and followed up during their recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This study reports 16 patients with a mean age of 48\u2009years old. Brown tumor lesions were associated with primary hyperparathyroidism in 6 cases (38%), secondary hyperparathyroidism to chronic kidney failure in 5 cases (31%), and tertiary hyperparathyroidism in the context of a long lasting CRI in 5 cases. Their location was maxillary in 7 cases, mandibular in 5 cases, and bimaxillary in 4 cases. The treatment consisted of parathyroidectomy in 13 patients, maxillary resection in 3 cases, and vitamin D treatment in 2 cases. Favorable outcomes, characterized by tumor regression, were reported in 9 cases, whereas unfavorable evolution was observed among 7 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Parathyroidectomy is the gold standard treatment for primary hyperparathyroidism. It resulted in a total regression in all our cases. Regarding secondary hyperparathyroidism, blood screening and chronic renal insufficiency follow-up are critically valuable to detect this condition at an early stage, hence increasing the success rate of brown tumor regression. Our secondary and tertiary hyperparathyroidism results were miscellaneous; although it is important to emphasize the importance of the chronic renal insufficiency management to ensure a success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance:<\/jats:title>\n                    <jats:p>Brown tumors should be included in the differential diagnosis of giant cell lesions. Parathyroidectomy is usually sufficient to induce the total regression of the lesion in primary hyperparathyroidism cases. A more delicate approach is needed regarding secondary hyperparathyroidism. Meticulous control of chronic renal insufficiency is mandatory in addition to parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795514231210143","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:11:50Z","timestamp":1699315910000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Brown Tumors of the Jaws: A Retrospective Study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-9908","authenticated-orcid":false,"given":"Maya","family":"Fedhila","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-3487","authenticated-orcid":false,"given":"Raouaa","family":"Belkacem Chebil","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Marmouch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology,Fattouma Bourguiba Hospital, Faculty of Medicine of Monastir, University of Monastir,Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrine","family":"Terchalla","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Ayachi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Sahloul Hospital (Sousse), Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Oueslati","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Oualha","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabiha","family":"Douki","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Sahloul Hospital (Sousse), Faculty of Dental Medicine of Monastir, University of Monastir, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Khochtali","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Sahloul Hospital (Sousse), Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"bibr1-11795514231210143","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-13-00225.1"},{"key":"bibr2-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.02.002"},{"key":"bibr3-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12284"},{"key":"bibr4-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011877"},{"key":"bibr5-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(01)00099-2"},{"key":"bibr6-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23631"},{"key":"bibr7-11795514231210143","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-016-0575-0"},{"key":"bibr8-11795514231210143","doi-asserted-by":"crossref","unstructured":"World Medical Association. Declaration of Helsinki: Ethical principles for medical research involving human subjects. 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Les tumeurs brunes osseusesde l\u2019hyperparathyro\u00efdie. 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