{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:01:39Z","timestamp":1778252499937,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the association of insulin resistance (IR) in the pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), few studies have evaluated the utility of acanthosis nigricans (AN) as a clinical predictor for this condition. Thus, we aimed to determine the role of AN as a risk factor and clinical predictor of MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study conducted a comprehensive clinical history and physical examination. The presence of acanthosis nigricans was assessed in the neck, elbows, axillae, and knuckles. Liver biochemical parameters were measured, hepatic fat was analyzed using the controlled attenuation parameter (CAP), while hepatic stiffness was evaluated in kilopascals (kPA) with the FibrosScan 530 Compact and Smart Exam software. Multiple analyses were performed to determine the relationship between acanthosis nigricans and MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We recruited 251 adult participants. The mean BMI was 29.9\u2009\u00b1\u20097.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , including 40.2% of participants with obesity and 63.7% with AN. Transient elastography evaluation resulted in 65.7% and 6% participants with hepatic steatosis (S3, 48.6%) and fibrosis, respectively. A non-adjusted (OR 2.63, 95% CI 1.57-4.52) and adjusted model (OR 1.97, 95% CI 0.95-4.12) were determined for AN as a risk factor for liver steatosis. Furthermore, the presence of AN in knuckles resulted in an association to predict liver steatosis (OR 2.09, 95% CI 1.01-4.35), while a multivariate analysis indicated that AN predicts a higher steatosis grade (S2 OR\u2009=\u20096.58, CI 95% 1.18-36.53; S3 OR\u2009=\u20092.36, CI 95% 1.04-5.3).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Acanthosis nigricans demonstrated to predict a higher steatosis grade in adults with overweight and obesity. Our study supports the clinical applicability of AN as a screening tool for MASLD to identify high-risk subjects in resource-limited settings. Additional studies are needed to define alternative diagnostic tools for the early identification of metabolic risk factors in populations with specific clinical or demographic characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795514251345047","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:38:38Z","timestamp":1749861518000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acanthosis Nigricans as a Clinical Risk Marker for Metabolic Dysfunction-Associated Steatotic Liver Disease"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7429","authenticated-orcid":false,"given":"Adriana","family":"S\u00e1nchez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Endocrinology Division, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Penados-Ovalle","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Rodr\u00edguez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"},{"name":"Centro de An\u00e1lisis Avanzado de Informaci\u00f3n Cient\u00edfica 360, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"},{"name":"Knowledge and Evaluation Research Unit in Endocrinology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"D\u00edaz-Gonz\u00e1lez Colmeneros","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Gerardo","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Facultad de Medicina y Hospital Universitario \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.03.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2019-00034"},{"issue":"4","key":"e_1_3_3_5_2","first-page":"453","article-title":"Prevalencia de h\u00edgado graso no alcoh\u00f3lico y s\u00edndrome metab\u00f3lico en poblaci\u00f3n asintom\u00e1tica","volume":"71","author":"Lizardi-Cervera J","year":"2006","unstructured":"Lizardi-Cervera J, Laparra DI, Ch\u00e1vez-Tapia NC, Ostos ME, Esquivel MU. Prevalencia de h\u00edgado graso no alcoh\u00f3lico y s\u00edndrome metab\u00f3lico en poblaci\u00f3n asintom\u00e1tica. Rev Gastroenterol M\u00e9x. 2006;71(4):453-459.","journal-title":"Rev Gastroenterol M\u00e9x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14595"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.400"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2018.1471958"},{"key":"e_1_3_3_9_2","first-page":"27","article-title":"Implications of a clinically ignored site of acanthosis nigricans: the knuckles","volume":"123","author":"G\u00f3mez-Flores M","year":"2015","unstructured":"G\u00f3mez-Flores M, Gonz\u00e1lez-Saldivar G, Santos-Santos O, et al. Implications of a clinically ignored site of acanthosis nigricans: the knuckles. Exp Clin Endocrinol Diabetes. 2015;123(01):27-33.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0348-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13453"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.4.371"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05831.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2024.01.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2018.11.007"},{"key":"e_1_3_3_16_2","unstructured":"Weir CB Jan A. BMI Classification Percentile and Cut Off Points. [Updated 2023 June 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541070\/"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25993"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.018"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.21149\/11630"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0461-7"},{"issue":"27","key":"e_1_3_3_21_2","first-page":"24","article-title":"Hepatic steatosis and acanthosis nigricans in obese adolescents aged 15 to 19 years with high risk of diabetes mellitus according to the Findrisk test","volume":"9","author":"Ak\u00e9-Canch\u00e9 B","year":"2022","unstructured":"Ak\u00e9-Canch\u00e9 B, Vel\u00e1zquez-Sarabia BM, Sarabia-Alcocer B, L\u00f3pez-Guti\u00e9rrez TJ. Hepatic steatosis and acanthosis nigricans in obese adolescents aged 15 to 19 years with high risk of diabetes mellitus according to the Findrisk test. 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