{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:44:07Z","timestamp":1777585447968,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Wilson\u2019s disease (WD) is a rare genetic disorder that impairs copper metabolism, leading to its deposition in various organs, including the liver, brain, and cornea. Endocrine disorders, particularly hyperparathyroidism, are uncommon in WD. Methanol toxicity, a medical emergency, is rarely associated with WD and hyperparathyroidism, making this case particularly unique. We report a rare instance of this complex triad.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>A 53-year-old male with untreated WD presented with nausea, vomiting, dizziness, and blurred vision after ingesting methanol. Clinical examination revealed optic neuropathy, consistent with methanol toxicity, despite normal fundoscopy. Laboratory investigations revealed significant hypercalcemia and elevated parathyroid hormone (PTH) levels, confirming hyperparathyroidism. Imaging, including a prior technetium-99m sestamibi scan, indicated hyperfunctioning parathyroid tissue. Dialysis was initiated for methanol toxicity, and metabolic acidosis was corrected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case emphasizes the rare coexistence of WD, hyperparathyroidism, and methanol toxicity, presenting significant diagnostic and therapeutic challenges. The pathophysiological interactions between these conditions are not well understood and warrant further research to improve management strategies and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795514251376459","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:57:26Z","timestamp":1758045446000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Hyperparathyroidism and Wilson\u2019s Disease in a Patient With Methanol Toxicity: A Rare Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"Fatemeh","family":"Mohammadzadeh","sequence":"first","affiliation":[{"name":"Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Golestan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-9615","authenticated-orcid":false,"given":"Alireza","family":"Fatemi","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Yazdooei","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Norouzi","sequence":"additional","affiliation":[{"name":"Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i14.4334"},{"issue":"9","key":"e_1_3_3_3_2","article-title":"Wilson\u2019s disease manifestation in late adulthood: a case report and literature review","volume":"14","author":"Tazin F","year":"2022","unstructured":"Tazin F, Kumar H, Orlang V. Wilson\u2019s disease manifestation in late adulthood: a case report and literature review. Cureus. 2022;14(9):e29797.","journal-title":"Cureus"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1091580"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2022.12.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000384"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.483"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000150"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.141383"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.3.568"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050893"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4714"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6001014"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03178-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.109689"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.ijem_420_21"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14323"},{"issue":"2","key":"e_1_3_3_18_2","article-title":"Beyond the norm: unusual coexistence of Wilson\u2019s disease and hypoparathyroidism","volume":"16","author":"Sawant R","year":"2024","unstructured":"Sawant R, Chaudhari P, Hamdulay KF, Kumar S, Acharya S. Beyond the norm: unusual coexistence of Wilson\u2019s disease and hypoparathyroidism. Cureus. 2024;16(2):e54516.","journal-title":"Cureus"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193075"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cdt3.123"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2019.87622"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03202-0"},{"issue":"5","key":"e_1_3_3_23_2","first-page":"395","article-title":"Severe optic disc cupping following the methanol toxicity in a 20-year-old man: a case report","volume":"46","author":"Hassanpoor N","year":"2021","unstructured":"Hassanpoor N, Niyousha M. Severe optic disc cupping following the methanol toxicity in a 20-year-old man: a case report. 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