{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:10:39Z","timestamp":1789398639870,"version":"build-2803163510"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Ketosis-prone diabetes (KPD) is a heterogeneous diabetes phenotype in which some patients with preserved \u03b2-cell function can achieve insulin independence after diabetic ketoacidosis (DKA). The role of sodium-glucose cotransporter 2 (SGLT2) inhibitors in maintaining remission in A\u2212\u03b2+ KPD remains uncertain because of concerns regarding ketoacidosis risk. We report the case of a 45-year-old man who presented with severe DKA and was classified as A\u2212\u03b2+ KPD based on negative islet autoantibodies and preserved C-peptide secretion. Following acute management, structured insulin withdrawal was performed, and dapagliflozin was initiated at week 4 with intensive metabolic monitoring. Over 12 months, the patient achieved sustained insulin-free remission, with significant improvements in HbA1c (12.1% to 6.4%), robust recovery of stimulated C-peptide (peak 4.8 ng\/mL), and a continuous glucose monitoring (CGM) time-in-range of 82%, without recurrence of ketosis. This case suggests that in carefully selected A\u2212\u03b2+ KPD patients with preserved \u03b2-cell reserve, SGLT2 inhibition may be safely integrated into the remission phase under close surveillance. However, these findings are hypothesis-generating, and the contribution of dapagliflozin to remission cannot be determined from a single uncontrolled observation. Prospective studies are required before this strategy can be recommended for routine use.<\/jats:p>","DOI":"10.1177\/11795514261490259","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:23:50Z","timestamp":1789143830000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Durable Insulin-free Remission in A\u2212\u03b2+ Ketosis-Prone Diabetes With SGLT2 Inhibition: A Case Report With Longitudinal C-Peptide and CGM Data"],"prefix":"10.1177","volume":"19","author":[{"given":"Ahmadjon","family":"Ahmadjonov","sequence":"first","affiliation":[{"name":"Kokand University Andijan Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durr-e-shahwar","family":"Malik","sequence":"additional","affiliation":[{"name":"A.O Clinic\/Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otabek","family":"Kuziev","sequence":"additional","affiliation":[{"name":"Alfraganus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakhnoza","family":"Toshova","sequence":"additional","affiliation":[{"name":"Termez University of Economics and Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Smerat","sequence":"additional","affiliation":[{"name":"Al-Ahliyya Amman University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-6742","authenticated-orcid":false,"given":"Mohammad","family":"Adi","sequence":"additional","affiliation":[{"name":"Damascus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Tanta University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030180"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0026"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0749"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-5-200603070-00011"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1075-4"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2022.06.005"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14050264"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.108100"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0798"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01724.x"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1884"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100176"}],"container-title":["Clinical Medicine Insights: Endocrinology and Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795514261490259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795514261490259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795514261490259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:46:18Z","timestamp":1789397178000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795514261490259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":12,"alternative-id":["10.1177\/11795514261490259"],"URL":"https:\/\/doi.org\/10.1177\/11795514261490259","relation":{},"ISSN":["1179-5514","1179-5514"],"issn-type":[{"value":"1179-5514","type":"print"},{"value":"1179-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"11795514261490259"}}