{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:15:30Z","timestamp":1779250530098,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Gastroenterol"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of omeprazole-domperidone combination vs omeprazole monotherapy in gastroesophageal reflux disease (GERD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a comparative, randomized controlled, phase 4 study, outpatients with GERD were randomly allocated to either group 1 (omeprazole 20\u2009mg\u2009+\u2009domperidone 30\u2009mg) or group 2 (omeprazole 20\u2009mg) in an equal ratio; 2 capsules daily in the morning were administered for 8\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty patients were enrolled. Esophagitis reversal was observed in 92% patients in group 1 vs 65.2% in group 2. Approximately, 83.3% patients in group 1 vs 43.3% patients in group 2 demonstrated full cupping of reflux symptoms at 8\u2009weeks. Combined therapy resulted in significantly longer period of heartburn-free days (23 vs 12\u2009days on omeprazole). There were no safety concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Omeprazole-domperidone combination was more effective than omeprazole alone in providing complete cupping of reflux symptoms and healing of esophagitis in patients with GERD. Both the treatments were well tolerated with few reports of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>This trial is registered with http:\/\/clinicaltrials.gov , number NCT02140073.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1179552217709456","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T05:55:13Z","timestamp":1496210113000},"page":"117955221770945","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease"],"prefix":"10.1177","volume":"10","author":[{"given":"KY","family":"Marakhouski","sequence":"first","affiliation":[{"name":"Diagnostic Department, Republican Research and Practical Center for Pediatric Surgery, Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GA","family":"Karaseva","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutritiology, State Educational Establishment \u201cBelarusian Medical Academy of Post-Graduate Education,\u201d Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DN","family":"Ulasivich","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutritiology, State Educational Establishment \u201cBelarusian Medical Academy of Post-Graduate Education,\u201d Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y Kh","family":"Marakhouski","sequence":"additional","affiliation":[{"name":"Department of 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