{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:39:25Z","timestamp":1787499565792,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cancer cachexia is one of the most frequent effects of malignancy, is often associated with poor prognosis, and may account for up to 20% of cancer deaths. The aim of our study was to evaluate the relationship of cancer cachexia and serum levels of resistin and leptin in patients with advanced non\u2013small cell lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 67 chemotherapy-na\u00efve patients with advanced-stage non\u2013small cell cancer and a control group containing 20 healthy individuals without a known chronic disease were enrolled in this study. All individuals in the control group were age and sex matched. Demographic, anthropometric, laboratory data and serum levels of adipokines were measured for 2 groups. Progression-free survival and overall survival were estimated using the Kaplan-Meier method. Survival among various factors was calculated using the log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients presented significantly higher serum resistin ( P\u2009=\u2009.0001) and lower serum leptin levels ( P\u2009=\u2009.025) than the control group. Lower serum levels of leptin were correlated with overall survival ( P\u2009=\u2009.011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Serum leptin and resistin levels play key role as proinflammatory cytokines in lung cancer and cancer cachexia; however, their use as diagnostic or prognostic markers is not possible yet, and further large-scale studies are required to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1179554917690144","type":"journal-article","created":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T22:21:58Z","timestamp":1488752518000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Effects of Serum Leptin and Resistin Levels on Cancer Cachexia in Patients With Advanced-Stage Non\u2013Small Cell Lung Cancer"],"prefix":"10.1177","volume":"11","author":[{"given":"G\u00f6kcen","family":"Demiray","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Zafer Goksin Oncology Center, Denizli State Hospital, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"De\u011firmencio\u011flu","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fahri Goksin Oncology Center, Pamukkale University Hospital, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"U\u011furlu","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Department, Pamukkale University Hospital, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Yaren","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fahri Goksin Oncology Center, Pamukkale University Hospital, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"bibr1-1179554917690144","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S40479"},{"key":"bibr2-1179554917690144","first-page":"1521","volume":"18","author":"Fortunati N","year":"2007","journal-title":"Oncol Rep"},{"key":"bibr3-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000165004.93707.88"},{"key":"bibr4-1179554917690144","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S30891"},{"key":"bibr5-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.01.013"},{"key":"bibr6-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.09.009"},{"key":"bibr7-1179554917690144","doi-asserted-by":"publisher","DOI":"10.2174\/138955707779317821"},{"key":"bibr8-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032482"},{"key":"bibr9-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.06.005"},{"key":"bibr10-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200709020-00009"},{"key":"bibr11-1179554917690144","first-page":"1","volume":"9","author":"Lebovitz HE","year":"2002","journal-title":"Science"},{"key":"bibr12-1179554917690144","unstructured":"World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a WHO consultation, WHO Technical Report Series no. 894. Published 2000. Geneva, Switzerland: WHO."},{"key":"bibr13-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2005.09.005"},{"key":"bibr14-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1_suppl.97S"},{"key":"bibr15-1179554917690144","first-page":"86","volume":"17","author":"Scangliotti GV","year":"2001","journal-title":"Eur Respir Monogr"},{"key":"bibr16-1179554917690144","first-page":"772","volume":"9","author":"Lasheen W","year":"2009","journal-title":"Support Care Cancer"},{"key":"bibr17-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108325076"},{"key":"bibr18-1179554917690144","first-page":"409","volume":"26","author":"Emral R","year":"2006","journal-title":"J Med Sci"},{"key":"bibr19-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21690"},{"key":"bibr20-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-008-0605-y"},{"key":"bibr21-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-4-29"},{"key":"bibr22-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.05.047"},{"key":"bibr23-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.02.006"},{"key":"bibr24-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1051"},{"key":"bibr25-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9806134"},{"key":"bibr26-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm033"},{"key":"bibr27-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.03.017"},{"key":"bibr28-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00149.x"},{"key":"bibr29-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.01.018"},{"key":"bibr30-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1159\/000177952"},{"key":"bibr31-1179554917690144","doi-asserted-by":"crossref","first-page":"233","DOI":"10.33549\/physiolres.930848","volume":"55","author":"Housa D","year":"2006","journal-title":"Physiol Res"},{"key":"bibr32-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0467"},{"key":"bibr33-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1159\/000111097"},{"key":"bibr34-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm464"},{"key":"bibr35-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.033464"},{"key":"bibr36-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.02.004"},{"key":"bibr37-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000217899.59820.9a"},{"key":"bibr38-1179554917690144","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700050"},{"key":"bibr39-1179554917690144","first-page":"29","volume":"3","author":"Pang SS","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"bibr40-1179554917690144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5789"},{"key":"bibr41-1179554917690144","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.1.117"}],"container-title":["Clinical Medicine Insights: Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179554917690144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179554917690144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179554917690144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:36:44Z","timestamp":1777693004000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179554917690144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":41,"alternative-id":["10.1177\/1179554917690144"],"URL":"https:\/\/doi.org\/10.1177\/1179554917690144","relation":{},"ISSN":["1179-5549","1179-5549"],"issn-type":[{"value":"1179-5549","type":"print"},{"value":"1179-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"1179554917690144"}}