{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:09:47Z","timestamp":1793372987317,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Central venous access is needed to facilitate chemotherapy for many cancer patients. Central venous catheter-related thrombosis (CVCT) is a major complication that can cause significant morbidity and mortality. We sought to explore the rate of CVCT in a general cancer population in Australia and to identify factors associated with increased risk of thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a multi-centre retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and participants:<\/jats:title>\n                    <jats:p>We analysed key patient, treatment, and cancer-related factors for 317 patients with cancer and central venous catheters inserted for systemic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures:<\/jats:title>\n                    <jats:p>Symptomatic CVCT confirmed with imaging and management of patients with CVCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 402 cases of central line insertion were analysed. Central venous catheter-related thrombosis occurred in 24 patients (6.0%). Having a peripherally inserted central catheter (PICC; HR = 3.78, 95% CI = 1.28-11.19, P\u2009=\u2009.02) compared with an implantable port and a body mass index of \u2a7e25.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (HR = 3.60, 95% CI = 1.31-9.85, P\u2009=\u2009.01) were independently associated with increased risk of thrombosis. Central venous catheter-related thrombosis was managed mostly with removal of the catheter (19 of 24 cases) and anticoagulation, including direct-acting oral anticoagulants in 5 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This work explored rates of CVCT in a general cancer population, observing increased rates in those with PICCs or increased body mass index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1179554920953097","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T23:24:52Z","timestamp":1598829892000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Central Venous Catheter Thrombosis in Cancer: A Multi-Centre Retrospective Study Investigating Risk Factors and Contemporary Trends in Management"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-1223","authenticated-orcid":false,"given":"Lucy","family":"Haggstrom","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The Wollongong Hospital, Wollongong, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdeep","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Wollongong Hospital, Wollongong, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brungs","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Wollongong Hospital, Wollongong, NSW, Australia"},{"name":"Illawarra Health & Medical Research Institute, Wollongong, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"bibr1-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.715"},{"key":"bibr2-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04817.x"},{"key":"bibr3-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02374.x"},{"key":"bibr4-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-460121"},{"key":"bibr5-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02450.x"},{"key":"bibr6-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13505"},{"key":"bibr7-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12180"},{"key":"bibr8-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2014.1.306"},{"key":"bibr9-1179554920953097","unstructured":"Australian Bureau of Statistics. Frequently Asked Questions [Internet]. 2019. https:\/\/www.abs.gov.au\/websitedbs\/D3310114.nsf\/home\/Frequently+Asked+Questions."},{"key":"bibr10-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12474"},{"key":"bibr11-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"bibr12-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001275"},{"key":"bibr13-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.10.021"},{"key":"bibr14-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780122413"},{"key":"bibr15-1179554920953097","volume-title":"Cancer in Australia 2019 Canberra (CAN 123)","author":"Australian Institute of Health and Welfare","year":"2019"},{"key":"bibr16-1179554920953097","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01217"},{"key":"bibr17-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2020.01.010."},{"key":"bibr18-1179554920953097","volume":"130","author":"Ellis ML","year":"2020","journal-title":"Intern Med J"},{"key":"bibr19-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-019-0191-y"},{"key":"bibr20-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14568705"},{"key":"bibr21-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1177\/0300060514527061"},{"key":"bibr22-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-427708"},{"key":"bibr23-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.01.027"},{"key":"bibr24-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1159\/000339308"},{"key":"bibr25-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.135"},{"key":"bibr26-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12549"},{"key":"bibr27-1179554920953097","volume":"6","author":"Kahale LA","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr28-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814468"},{"key":"bibr29-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814630"},{"key":"bibr30-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017894"},{"key":"bibr31-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30336-5"},{"key":"bibr32-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213940"},{"key":"bibr33-1179554920953097","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24588"}],"container-title":["Clinical Medicine Insights: Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179554920953097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179554920953097","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179554920953097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:37:22Z","timestamp":1777693042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179554920953097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":33,"alternative-id":["10.1177\/1179554920953097"],"URL":"https:\/\/doi.org\/10.1177\/1179554920953097","relation":{},"ISSN":["1179-5549","1179-5549"],"issn-type":[{"value":"1179-5549","type":"print"},{"value":"1179-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1179554920953097"}}