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BC in CML is mediated by aberrant tyrosine kinase activity of the BCR::ABL fusion protein. The introduction of BCR::ABL tyrosine kinase inhibitor (TKI) has been a gamechanger in the treatment of CML and there has been a significant reduction in the incidence of BC. The main treatment goal in BC is to achieve a second CP and consolidate that with an allogeneic stem cell transplantation (SCT) in eligible patients. The outcomes in BC remain dismal even in the current era. In this review, we provide an overview of the biology and current therapeutic approach in myeloid BC.<\/jats:p>","DOI":"10.1177\/11795549221139357","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T02:08:05Z","timestamp":1670206085000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Current Management of Chronic Myeloid Leukemia Myeloid Blast Phase"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-329X","authenticated-orcid":false,"given":"Binoy","family":"Yohanan","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binsah","family":"George","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, The University of Texas Health Science 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