{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:17:03Z","timestamp":1777936623279,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"A cohort study of lung cancer in Beijing Chest Hospital affiliated to Capital Medical University","award":["2018-02-01"],"award-info":[{"award-number":["2018-02-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have limited or no response in some certain patients of non-small-cell lung cancer (NSCLC). However, real-world survival analyses comparing clinical data and EGFR-plasma mutation are still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In total, 159 patients with advanced NSCLC resistant to first-generation EGFR-TKIs were included for consecutive blood sampling in this study. Super-amplification refractory mutation system (Super-ARMS) was used to detect EGFR-plasma mutations and correlations between survival and circulating tumor DNA (ctDNA) were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 159 eligible patients, the T790M mutation was detected in 27.0% (43\/159) of patients. The median progression-free survival (mPFS) was 10.7\u2009months in all patients. Survival analysis revealed that patients with the T790M mutation had shorter progression-free survival (PFS) than those with the T790M wild-type (10.6\u2009months vs 10.8\u2009months, P\u2009=\u2009.038). Patients who cleared EGFR-plasma mutation had prolonged PFS compared with those with nonclearing EGFR-plasma mutation (11.6\u2009months vs 9.0\u2009months, P\u2009=\u2009.001). Cox multivariate analysis showed that the nonclearance of EGFR-plasma mutations was an independent risk factor for PFS (RR\u2009=\u20091.745, 95% CI: [1.184, 2.571], P\u2009=\u2009.005). The T790M mutation was associated with nonclearance of the EGFR-plasma mutation ( \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200910.407, P\u2009=\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with advanced NSCLC who were resistant to the first-generation EGFR-TKI had a prolonged PFS with clearance of EGFR-plasma mutation. Those nonclearers were more likely to harbor T790M mutations in plasma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795549231176398","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T13:59:31Z","timestamp":1687528771000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Analysis of 159 Patients With Advanced Non-Small-Cell Lung Cancer Resistant to First-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-1381","authenticated-orcid":false,"given":"Aimin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Medical Records, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"bibr1-11795549231176398","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.8456"},{"key":"bibr2-11795549231176398","first-page":"239","volume":"13","author":"Rosell 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