{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:36:34Z","timestamp":1793932594995,"version":"4.8.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the special project of clinical research on truth-seeking","award":["ZL202210"],"award-info":[{"award-number":["ZL202210"]}]},{"name":"the talents program of Jiangsu Cancer Hospital","award":["YC201801"],"award-info":[{"award-number":["YC201801"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Following changes in primary tumor (T) and lymph node (N) staging for nasopharyngeal carcinoma (NPC) in the Eighth Edition AJCC Cancer Staging Manual, simplification of T staging has been proposed. However, a limited range of 2-deoxy-2-[fluorine-18] fluoro-D-glucose positron emission tomography\u2013computed tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\u2013CT) metabolic parameters has been investigated. Therefore, we aimed to evaluate the primary tumor invasiveness and the lymph node metastasis (LNM) of NPC from a metabolic perspective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 435 NPC patients underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/CT before treatment were retrospectively examined. The primary endpoint was differences in standard uptake value (SUV), lean body mass-normalized SUV (SUL), body surface area-normalized SUV (SUS), glucose-normalized SUV (GN), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and glucose-normalized total lesion glycolysis (GNTLG) of primary tumors and LNM between different T and N stages. The metabolic parameters associated with T and N staging were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were significant differences between all parameters relative to the primary tumor but no significant differences in any parameter relative to the LNM and T stages. Higher mean values of TGN\n                      <jats:sub>max<\/jats:sub>\n                      , TGN\n                      <jats:sub>mean<\/jats:sub>\n                      , TSUV\n                      <jats:sub>peak<\/jats:sub>\n                      , and TSUS\n                      <jats:sub>max<\/jats:sub>\n                      were associated with advanced T stages. Higher mean values of all the LNM parameters were associated with more advanced N stages. Only primary tumor metabolic tumor volume (TMTV), TSUV\n                      <jats:sub>peak<\/jats:sub>\n                      , TSUL\n                      <jats:sub>max<\/jats:sub>\n                      , and TSUS\n                      <jats:sub>max<\/jats:sub>\n                      showed a significant positive association with T staging, while lymph node metabolic tumor volume (LNMTV) and TSUS\n                      <jats:sub>max<\/jats:sub>\n                      were significantly positive in N staging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that metabolic parameters are useful indicators of tumor invasiveness and LNM based on the Eighth Edition manual. Compared with volume-dependent parameters, TGN\n                      <jats:sub>max<\/jats:sub>\n                      , TGN\n                      <jats:sub>mean<\/jats:sub>\n                      , TSUV\n                      <jats:sub>peak<\/jats:sub>\n                      , and TSUS\n                      <jats:sub>max<\/jats:sub>\n                      may be better indicators of local tumor aggressiveness. SUS\n                      <jats:sub>max<\/jats:sub>\n                      of the primary tumor was associated with LNM. In addition to SUV\n                      <jats:sub>max<\/jats:sub>\n                      , other metabolic parameters (eg, SUL\n                      <jats:sub>max<\/jats:sub>\n                      , SUS\n                      <jats:sub>max<\/jats:sub>\n                      , GN\n                      <jats:sub>max<\/jats:sub>\n                      , and GN\n                      <jats:sub>mean<\/jats:sub>\n                      ) could evaluate tumor aggressiveness and LNM better.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795549231225419","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T04:44:21Z","timestamp":1707108261000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Utility of\n                    <sup>18<\/sup>\n                    F-FDG-PET\u2013CT Metabolic Parameters in Evaluating the Primary Tumor Aggressiveness and Lymph Node Metastasis of Nasopharyngeal Carcinoma"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-0068","authenticated-orcid":false,"given":"Yun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of PET\/CT Center, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of PET\/CT Center, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of PET\/CT Center, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7055-5751","authenticated-orcid":false,"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of PET\/CT Center, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"bibr1-11795549231225419","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"bibr2-11795549231225419","unstructured":"Ferlay J, Ervik M, Lam F, et al. 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