{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:03:59Z","timestamp":1791903839076,"version":"4.3.4"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Major Science and Technology Project of the Zhejiang Provincial Department of Science and Technology","award":["grant no. 2020C03030"],"award-info":[{"award-number":["grant no. 2020C03030"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Helicobacter pylori ( H pylori), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, linking it to other gastrointestinal malignancies, such as esophageal cancer, liver cancer, pancreatic cancer, gallbladder cancer, and colorectal cancer. In light of the expanding research landscape and the increasing interest in exploring H pylori broader role in gastrointestinal tumorigenesis, this comprehensive review aims to elucidate the relationship between H pylori and gastrointestinal tumors. This review encompasses recent epidemiological studies, research progress, and emerging perspectives, providing a comprehensive assessment of the relationship between H pylori and gastrointestinal tumors. The findings highlight the captivating world of H pylori and its intricate involvement in gastrointestinal malignancies.<\/jats:p>","DOI":"10.1177\/11795549241234637","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T05:54:50Z","timestamp":1711605290000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>Helicobacter pylori<\/i>\n                    and Gastrointestinal Cancers: Recent Advances and Controversies"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3100-2415","authenticated-orcid":false,"given":"Chuandong","family":"Zhang","sequence":"first","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"},{"name":"Department of Clinical Medicine, Qingdao Medical College, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"},{"name":"Department of Clinical Medicine, Qingdao Medical College, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Long","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"},{"name":"Department of Clinical Medicine, Bengbu Medical College, Bengbu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Jing","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, China"},{"name":"Zhejiang Provincial Engineering Laboratory of Diagnosis, Treatment and Pharmaceutical Development of Gastrointestinal Tract Tumors, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"bibr1-11795549241234637","volume":"14","author":"Alkhaldi NK","year":"2022","journal-title":"Cureus"},{"key":"bibr2-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"bibr3-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00523.x"},{"key":"bibr4-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1086\/341245"},{"key":"bibr5-11795549241234637","first-page":"588","volume":"58","author":"Chow WH","year":"1998","journal-title":"Cancer Res"},{"key":"bibr6-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00602-0"},{"key":"bibr7-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0070-3"},{"key":"bibr8-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114012"},{"key":"bibr9-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1953497"},{"key":"bibr10-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0962-5"},{"key":"bibr11-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00484.x"},{"key":"bibr12-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01869-15"},{"key":"bibr13-11795549241234637","first-page":"6735","volume":"52","author":"Correa P.","year":"1992","journal-title":"Cancer Res"},{"key":"bibr14-11795549241234637","volume":"7","author":"Ford AC","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr15-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00164-X"},{"key":"bibr16-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12950"},{"key":"bibr17-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"bibr18-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12633"},{"key":"bibr19-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i44.9794"},{"key":"bibr20-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163700"},{"key":"bibr21-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"bibr22-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.083"},{"key":"bibr23-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.584"},{"key":"bibr24-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153811"},{"key":"bibr25-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds643"},{"key":"bibr26-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.010"},{"key":"bibr27-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.12.006"},{"key":"bibr28-11795549241234637","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15510"},{"key":"bibr29-11795549241234637","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1166"},{"key":"bibr30-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.12.937"},{"key":"bibr31-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq007"},{"key":"bibr32-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu240"},{"key":"bibr33-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.13.948"},{"key":"bibr34-11795549241234637","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v13.i8.835"},{"key":"bibr35-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-321"},{"key":"bibr36-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0185"},{"key":"bibr37-11795549241234637","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7946"},{"key":"bibr38-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1177\/20406223231155119"},{"key":"bibr39-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11815"},{"key":"bibr40-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389534"},{"key":"bibr41-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410009546"},{"key":"bibr42-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2654-1"},{"key":"bibr43-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8886085"},{"key":"bibr44-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0245-x"},{"key":"bibr45-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00719.x"},{"key":"bibr46-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.675747"},{"key":"bibr47-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.008"},{"key":"bibr48-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1080\/003655202753387455"},{"key":"bibr49-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040550"},{"key":"bibr50-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27193"},{"key":"bibr51-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2021.11.013"},{"key":"bibr52-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"bibr53-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520001208"},{"key":"bibr54-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001001)89:7<1431::AID-CNCR4>3.0.CO;2-5"},{"key":"bibr55-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.307"},{"key":"bibr56-11795549241234637","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i32.3617"},{"key":"bibr57-11795549241234637","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26042"},{"key":"bibr58-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcz157"},{"key":"bibr59-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.09.054"},{"key":"bibr60-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1545"},{"key":"bibr61-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr331"},{"key":"bibr62-11795549241234637","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000127"},{"key":"bibr63-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328075"},{"key":"bibr64-11795549241234637","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231170943"}],"container-title":["Clinical Medicine Insights: Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795549241234637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795549241234637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795549241234637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:39:13Z","timestamp":1777693153000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795549241234637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":64,"alternative-id":["10.1177\/11795549241234637"],"URL":"https:\/\/doi.org\/10.1177\/11795549241234637","relation":{},"ISSN":["1179-5549","1179-5549"],"issn-type":[{"value":"1179-5549","type":"print"},{"value":"1179-5549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"11795549241234637"}}