{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:17:53Z","timestamp":1777936673739,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Graduate ResearchInnovation Project in Jiangsu province","award":["No. SJCX22_1816"],"award-info":[{"award-number":["No. SJCX22_1816"]}]},{"name":"Highlevel talent \u201csix one projects\u201d top talent scientific research project of Jiangsu Province","award":["No. LGY2019034"],"award-info":[{"award-number":["No. LGY2019034"]}]},{"name":"the Academic Science and Technology Innovation Fund for College Students","award":["No. 202011117056Y"],"award-info":[{"award-number":["No. 202011117056Y"]}]},{"name":"Social development project of key R & D plan of Jiangsu Provincial Department of science and technology","award":["No. BE2022773"],"award-info":[{"award-number":["No. BE2022773"]}]},{"name":"the Social DevelopmentHealth Care Project of Yangzhou, Jiangsu Province","award":["No. YZ2021075"],"award-info":[{"award-number":["No. YZ2021075"]}]},{"name":"the Graduate Research Innovation Project in Jiangsu province","award":["No.SJCX21_1644"],"award-info":[{"award-number":["No.SJCX21_1644"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Accurate intraoperative navigation remains challenging in gastrointestinal tumor surgery. This study aims to explore the potential of optical coherence tomography (OCT) and endoscopic ultrasonography (EUS) in enhancing the accuracy of intraoperative navigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center diagnostic study was conducted at Northern Jiangsu People\u2019s Hospital from August to December 2024. This study is part of a prospective study, and more patients will be recruited in the future. The normal tissues, tumor tissues, vascular tissues, adipose tissues and lymph nodes of 12 patients with gastrointestinal tumors were collected for OCT and EUS scanning, and the image differences were compared. In addition, 43 lymph node specimens from 18 randomly selected patients were scanned by OCT and EUS, and pathological reports were used as the baseline. The results of OCT and EUS were compared retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There are notable differences between OCT and EUS imaging. EUS can capture images of the entire tissue layer, making it more effective than OCT in assessing tumor invasion depth. Conversely, OCT serves as an \u201coptical biopsy,\u201d providing higher precision in the early stages of lesions. Our further research indicates that the combined application of these modalities holds significant potential. In a double-blind evaluation of 43 lymph nodes from 18 randomly selected patients, OCT demonstrated a sensitivity of 81.25%, specificity of 88.89%, and a positive predictive value (PPV) of 81.25%. In comparison, EUS showed a sensitivity of 87.50%, specificity of 85.19%, and a PPV of 77.78%. The combined use of OCT and EUS achieved a sensitivity of 93.75%, specificity of 92.59%, and a PPV of 88.24%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The combined use of OCT and EUS can enhance sensitivity and specificity, thereby improving the accuracy of intraoperative navigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry (No. ChiCTR2400088875); Registered 28 August 2024, first patient enrolled 20 September 2024.<\/jats:p>\n                  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Clinical College of Xuzhou Medical University, Xuzhou Medical University, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7072-2649","authenticated-orcid":false,"given":"Jiahao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyu","family":"Wei","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daorong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Institute of General Surgery, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, Yangzhou, 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