{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:18:36Z","timestamp":1777936716294,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Pediatr"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Moraxella lacunata, a low-virulence Gram-negative coccobacillus, is classically associated with conjunctivitis and upper respiratory tract infections; systemic infections such as sepsis have rarely been reported, especially in children. We describe a 28-month-old girl with atypical hemolytic uremic syndrome and stage II chronic kidney disease on long-term eculizumab therapy who presented with systemic inflammatory response syndrome and was found to have Moraxella lacunata bloodstream infection. Eculizumab, a humanized monoclonal anti-C5 antibody, has been associated with susceptibility to infections with encapsulated bacteria, especially Neisseria meningitidis. This is the first report of an invasive bacterial infection with Moraxella lacunata in a pediatric eculizumab recipient.<\/jats:p>","DOI":"10.1177\/1179556521992367","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T22:08:34Z","timestamp":1612908514000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Eculizumab-Associated\n                    <i>Moraxella lacunata<\/i>\n                    Bacteremia and Systemic Inflammatory Response Syndrome in a Toddler with Atypical Hemolytic Uremic Syndrome"],"prefix":"10.1177","volume":"15","author":[{"given":"Paige S","family":"Bicoll","sequence":"first","affiliation":[{"name":"Beaumont Children\u2019s Hospital, Royal Oak, Michigan and Oakland University William Beaumont School of Medicine, Rochester, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashima","family":"Goyal","sequence":"additional","affiliation":[{"name":"Beaumont Children\u2019s Hospital, Royal Oak, Michigan and Oakland University William Beaumont School of Medicine, Rochester, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal B","family":"Blatt","sequence":"additional","affiliation":[{"name":"Beaumont Children\u2019s Hospital, Royal Oak, Michigan and Oakland University William Beaumont School of Medicine, Rochester, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-4356","authenticated-orcid":false,"given":"Bishara J","family":"Freij","sequence":"additional","affiliation":[{"name":"Beaumont Children\u2019s Hospital, Royal Oak, Michigan and Oakland University William Beaumont School of Medicine, Rochester, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"bibr1-1179556521992367","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1985.tb01558.x"},{"key":"bibr2-1179556521992367","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03985-7"},{"key":"bibr3-1179556521992367","first-page":"104","volume":"8","author":"Pavlatou M","year":"1953","journal-title":"Moraxella lacunata. 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