{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:18:53Z","timestamp":1777936733894,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"hamadan university of medical sciences","doi-asserted-by":"publisher","award":["9306182867"],"award-info":[{"award-number":["9306182867"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Pediatr"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Jaundice is one of the most common problems during infancy. It is believed that breast milk jaundice is one of the reasons for the persistence of jaundice after 14\u2009days of prolonged jaundice. This study evaluates the effect of Clofibrate and phototherapy on prolonged jaundice originating from breast milk in term and healthy neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials And Methods:<\/jats:title>\n                    <jats:p>This double-blind clinical trial study was performed on 100 randomly divided neonates in the neonatal ward of Besat Hospital. In addition to phototherapy, the case group received a single dose of edible Clofibrate (50\u2009mg\/kg) dissolved in 2 CCs of distilled water. The control group received the same amount of distilled water as the phototherapy group. After treatment, bilirubin change rate, duration of hospitalization, and any association with gender, gestational age, hemoglobin, blood type, and Rh of neonates were determined and compared throughout the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data analysis showed that the bilirubin reduction rate was statistically significantly higher in the case group than in the control group ( P\u2009&lt;\u2009.05). The mean duration of hospitalization and phototherapy in the case group was significantly lower than in the control group ( P\u2009=\u2009.005). The bilirubin reduction rate was not affected significantly by gestational age, blood type, or Rh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study\u2019s results demonstrated that Clofibrate effectively decreased bilirubin levels and shortened the duration of phototherapy and hospitalization in infants with probable breast milk jaundice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>IRCT2012092910933N1<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795565231177987","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:30:49Z","timestamp":1688110249000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Clofibrate and Phototherapy on Prolonged Jaundice due to Breast Milk in Full-Term Neonates"],"prefix":"10.1177","volume":"17","author":[{"given":"Fatemeh","family":"Eghbalian","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-2042","authenticated-orcid":false,"given":"Roya","family":"Raeisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Faradmal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Health, Modeling of Non communicable Diseases Research Center, Health Sciences and Technology Research Institute, Hamadan University of Medical Science, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Asgharzadeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"bibr1-11795565231177987","first-page":"753","volume-title":"Nelson Textbook of Pediatrics","volume":"102","author":"Behrman RE","year":"2021","edition":"16"},{"key":"bibr2-11795565231177987","first-page":"205","volume-title":"Martindale: Complete drug Reference","volume":"2004","author":"Watson VA","edition":"32"},{"key":"bibr3-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0098"},{"key":"bibr4-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0006-1"},{"key":"bibr5-11795565231177987","first-page":"349","volume":"10","author":"ZahedPY","year":"2007","journal-title":"Arch Iran Med"},{"key":"bibr6-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0184-x"},{"key":"bibr7-11795565231177987","first-page":"21","volume":"50","author":"Habibi M","year":"2012","journal-title":"Acta Med Iran"},{"key":"bibr8-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1007\/BF02760695"},{"key":"bibr9-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000105"},{"key":"bibr10-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2438-6"},{"key":"bibr11-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30139-1"},{"key":"bibr12-11795565231177987","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2360-y"},{"key":"bibr13-11795565231177987","volume":"12","author":"Gholitabar M","year":"2012","journal-title":"Cochrane Database Syst 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