{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:30:54Z","timestamp":1753882254028,"version":"3.41.2"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdWomens\ufffdHealth"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To assess the outcomes of Botulinum Toxin-A (BoNT-A) to the external urethral sphincter (EUS) in dysfunctional voiding (DV) refractory to standard urotherapy and bowel management. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Our criteria to diagnose DV in women included neurologically normal individuals with lower urinary tract symptoms, dilated proximal urethra on voiding cystourethrogram, and high detrusor pressure (PdetQmax\u2009&gt;\u200920\u2009cm H<jats:sub>2<\/jats:sub>O) associated with increased electromyography activity during voiding in urodynamic study (UDS). A total of 16 female patients with a median age of 36\u2009years (5-60\u2009years) received BoNT-A from June 2014 to December 2015. Patients below and above 10\u2009years of age received 100 units and 200 units of BoNT-A to EUS, respectively. Patients were followed up till 6\u2009months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Mean AUA (American Urological Association) symptom score decreased significantly from 11.75\u2009\u00b1\u20096.14 to 5.06\u2009\u00b1\u20095.1 and 4.25\u2009\u00b1\u20093.4 at day 14 and day 45 after BoNT-A, respectively ( P\u2009&lt;\u2009.0001). There were no significant improvements in maximal flow (Qmax) on uroflowmetry (UFM) and detrusor pressure at maximal flow (PdetQmax) in UDS. Significant reduction in post-void residual (PVR) from 69.31\u2009\u00b1\u200977.3 to 17.50\u2009\u00b1\u200922.3\u2009mL at day 14 ( P\u2009=\u2009.007) was observed, although the reduction was not significant at day 45. Although minor adverse effects were reported, none were serious or life-threatening. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Our study showed that BoNT-A plays a role in improvement of urinary symptoms and reduces PVR at D14 in DV, but showed no improvement in UFM and urodynamic parameters, albeit with limited numbers and limited follow-up. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1179562x18811340","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T10:27:01Z","timestamp":1542882421000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Prospective Study to Evaluate the Efficacy of Botulinum Toxin-A in the Management of Dysfunctional Voiding in Women"],"prefix":"10.1177","volume":"11","author":[{"given":"Pramod","family":"Krishnappa","sequence":"first","affiliation":[{"name":"Department of Urology, NU Hospitals, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneesh","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Urology, NU Hospitals, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Urology, NU Hospitals, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"doi-asserted-by":"publisher","key":"bibr1-1179562X18811340","DOI":"10.1016\/S0090-4295(02)02243-4"},{"doi-asserted-by":"publisher","key":"bibr2-1179562X18811340","DOI":"10.1016\/S0022-5347(05)67239-4"},{"doi-asserted-by":"publisher","key":"bibr3-1179562X18811340","DOI":"10.1159\/000473490"},{"doi-asserted-by":"publisher","key":"bibr4-1179562X18811340","DOI":"10.1007\/s001920070035"},{"doi-asserted-by":"publisher","key":"bibr5-1179562X18811340","DOI":"10.1016\/S0022-5347(06)00298-9"},{"doi-asserted-by":"publisher","key":"bibr6-1179562X18811340","DOI":"10.1016\/j.juro.2007.03.185"},{"doi-asserted-by":"publisher","key":"bibr7-1179562X18811340","DOI":"10.1016\/j.juro.2006.03.119"},{"doi-asserted-by":"publisher","key":"bibr8-1179562X18811340","DOI":"10.1016\/j.jpurol.2014.10.006"},{"doi-asserted-by":"publisher","key":"bibr9-1179562X18811340","DOI":"10.1016\/j.juro.2013.10.034"},{"doi-asserted-by":"publisher","key":"bibr10-1179562X18811340","DOI":"10.1016\/j.urology.2014.11.001"},{"doi-asserted-by":"publisher","key":"bibr11-1179562X18811340","DOI":"10.4103\/0970-1591.91429"},{"key":"bibr12-1179562X18811340","first-page":"365","volume":"28","author":"Steward JE","year":"2010","journal-title":"World J"},{"doi-asserted-by":"publisher","key":"bibr13-1179562X18811340","DOI":"10.1016\/j.eururo.2008.09.009"}],"container-title":["Clinical Medicine Insights: Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179562X18811340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179562X18811340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179562X18811340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T19:52:18Z","timestamp":1728417138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179562X18811340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":13,"alternative-id":["10.1177\/1179562X18811340"],"URL":"https:\/\/doi.org\/10.1177\/1179562x18811340","relation":{},"ISSN":["1179-562X","1179-562X"],"issn-type":[{"type":"print","value":"1179-562X"},{"type":"electronic","value":"1179-562X"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"1179562X18811340"}}