{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:08:06Z","timestamp":1783480086676,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rituximab is reserved for treating refractory myasthenia gravis (MG) patients. Here we report our experience with rituximab in AChR antibody positive generalized MG (gMG) and impending myasthenic crisis (IMC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, observational study, conducted at a tertiary care, neuroimmunology clinic, analyzed the data of patients with AChR antibody positive gMG, treated with rituximab between 1st January 2016 and 30th October 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eleven patients with AChR antibody positive gMG received rituximab. Mean age of the cohort was 50.54\u2009\u00b1\u200918.71\u2009years with 9 males. Seven out of 11 patients received rituximab in the early stage (&lt;2\u2009years from onset) and had good response to treatment. Four of the 5 patients with IMC improved with rituximab alone. In the 10 patients who regularly followed up, there was a significant difference between the QMG scores at baseline and at 1, 2, 6, 12, and 18\u2009months ( P\u2009&lt;\u2009.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Rituximab appears to be a potentially effective early treatment option for AChR antibody positive generalized MG and impending myasthenic crisis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795735211016080","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T01:23:51Z","timestamp":1621301031000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effective Early Treatment of AChR Antibody-Positive Myasthenia Gravis with Rituximab; the Experience from a Neuroimmunology Clinic in a Developing Country"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-8020","authenticated-orcid":false,"given":"Thomas","family":"Mathew","sequence":"first","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saji","family":"K John","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghunandan","family":"Nadig","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Badachi","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delon D","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRK","family":"Sarma","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth J","family":"Parry","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, 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