{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:37:58Z","timestamp":1777516678429,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015428","name":"BrainsWay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Epilepsy Therapy Project"},{"name":"Boston Children's Hospital Translational Research Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low frequency (\u22641\u00a0Hz) repetitive transcranial magnetic stimulation (rTMS) has been shown to suppress cortical excitability and is beginning to be trialed for the treatment of refractory epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>As a step toward a larger trial, the current pilot study was aimed to test the tolerability and safety of temporal lobe rTMS using H-coil for the treatment of temporal lobe epilepsy (TLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design<\/jats:title>\n                    <jats:p>1800 pulses of active or sham rTMS were applied 5\u00a0\u00a0days a week for 2\u00a0weeks over the temporal lobe of the affected hemisphere.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine participants were enrolled and randomized to verum or sham stimulation. One participant dropped out from the sham group after 5 rTMS sessions. In-session, 3 patients had typical seizures during sham stimulation. One patient had seizures also during active stimulation (albeit fewer than during sham). Minor reported adverse events during stimulation otherwise included transient neck pain and headache, and were reported in equal numbers in both groups. Major adverse events were not reported. Our results indicate that H-coil rTMS was well-tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the relatively high prevalence of individuals with TLE who are treatment-resistant and the preliminary results of this study, we suggest that a larger safety and efficacy trial of 1\u00a0Hz rTMS for the treatment of TLE is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795735221088522","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T07:54:21Z","timestamp":1652082861000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Preliminary Report of the Safety and Tolerability of 1\u00a0Hz Repetitive Transcranial Magnetic Stimulation in Temporal Lobe Epilepsy"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-9518","authenticated-orcid":false,"given":"Roman","family":"Gersner","sequence":"first","affiliation":[{"name":"Neuromodulation Program, Department of Neurology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay M.","family":"Oberman","sequence":"additional","affiliation":[{"name":"Neuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Neuromodulation Program, Department of Neurology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Chiriboga","sequence":"additional","affiliation":[{"name":"Neuromodulation Program, Department of Neurology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harper L","family":"Kaye","sequence":"additional","affiliation":[{"name":"Neuromodulation Program, Department of Neurology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Pascual-Leone","sequence":"additional","affiliation":[{"name":"Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Zangen","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Ben-Gurion University, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"Neuromodulation Program, Department of Neurology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"bibr1-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000218233.60217.84"},{"key":"bibr2-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22621"},{"key":"bibr3-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001280"},{"key":"bibr4-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001334"},{"key":"bibr5-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.035"},{"key":"bibr6-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011025.pub2"},{"key":"bibr7-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.06.002"},{"key":"bibr8-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31802fa393"},{"key":"bibr9-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.560"},{"key":"bibr10-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20199"},{"key":"bibr11-11795735221088522","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2010.510893"},{"key":"bibr12-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0188"},{"key":"bibr13-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2013.10.007"},{"key":"bibr14-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-11-13"},{"key":"bibr15-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2016.03.001"},{"key":"bibr16-11795735221088522","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.016"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735221088522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795735221088522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735221088522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:59:33Z","timestamp":1777391973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795735221088522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":16,"alternative-id":["10.1177\/11795735221088522"],"URL":"https:\/\/doi.org\/10.1177\/11795735221088522","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"value":"1179-5735","type":"print"},{"value":"1179-5735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"11795735221088522"}}