{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:45:08Z","timestamp":1778744708446,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Neurological manifestations of COVID-19 may affect both central and peripheral nervous systems. Unlike in adults, in whom majority of severe cases derive from respiratory complications, neurological involvement is one of the main causes of severe COVID-19 in children. This study aimed to detect viral respiratory pathogens, mainly SARS-CoV-2, in nasopharynx and cerebrospinal fluid samples utilizing qRT-PCR (TaqMan) in a pediatric population in Brazil. We evaluated four children with neurological symptoms and laboratory-confirmed SARS-CoV-2 infection: three presenting with meningoencephalitis and one presenting with Guillain-Barr\u00e9 syndrome. All four patients had mild respiratory symptoms. SARS-CoV-2 RNA was identified in two cerebrospinal fluid samples. SARS-CoV-2 involvement should be considered for differential diagnosis in pediatric cases presenting neurological alterations even if symptoms such as headache, anosmia, or dizziness are absent.<\/jats:p>","DOI":"10.1177\/11795735221102740","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:11:41Z","timestamp":1653264701000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurological Manifestations Associated With SARS-CoV-2 in Children: A Case Series"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-9297","authenticated-orcid":false,"given":"Marianna Tavares","family":"Venceslau","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana Pucarelli","family":"Lebreiro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielly de Souza","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda Klemm Arci Mattos de Freitas","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luane Abdalla","family":"Gouvea","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Mario Carmine","family":"Pastura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Dias","family":"Anachoreta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Cl\u00e1udia Silva","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Queiroz","family":"Maciel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Crespo","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezinha Marta Pereira Pinto","family":"Casti\u00f1eiras","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalita Fernandes","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Cisne","family":"Frota","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Brand\u00e3o","family":"Varella","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angelica Arpon Marandino","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Barroso","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil"},{"name":"Department of Pediatric Infectious Diseases, Instituto de Puericultura Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"bibr1-11795735221102740","unstructured":"World Health Organization. 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