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Two months into treatment with immunosuppressants, he developed devastating disseminated aspergillosis which clinically stabilized with aggressive antifungal treatment however had a protracted radiological course despite prolonged anti-fungal treatment for over two years. Interestingly, he remained in remission from neurosarcoidosis off immunosuppression during the same period.<\/jats:p>\n                  <jats:p>This case emphasizes need for vigilance for fungal infections in patients treated with combination immunosuppressive therapy particularly TNF-\u03b1 inhibitors such as infliximab.<\/jats:p>","DOI":"10.1177\/11795735231195756","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T07:44:13Z","timestamp":1691826253000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Disseminated Aspergillosis in a Patient With Neurosarcoidosis: Persistent Contrast Enhancement in CNS Despite Prolonged Antifungal Treatment: A Case Report"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-0610","authenticated-orcid":false,"given":"Lakshman","family":"Arcot Jayagopal","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-6426","authenticated-orcid":false,"given":"Afsaneh","family":"Shirani","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Cawcutt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Yuil-Valdes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Zabad","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"issue":"13","key":"bibr1-11795735231195756","first-page":"60680","volume":"383","author":"Valeyre D","year":"2014","journal-title":"Lancet"},{"key":"bibr2-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8479-6"},{"key":"bibr3-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90676-4"},{"key":"bibr4-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004644"},{"key":"bibr5-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60839-2"},{"key":"bibr6-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw444"},{"key":"bibr7-11795735231195756","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200721080-00004"},{"key":"bibr8-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318274cd77"},{"key":"bibr9-11795735231195756","doi-asserted-by":"publisher","DOI":"10.1086\/524669"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735231195756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795735231195756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735231195756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:59:41Z","timestamp":1777391981000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795735231195756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":9,"alternative-id":["10.1177\/11795735231195756"],"URL":"https:\/\/doi.org\/10.1177\/11795735231195756","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"value":"1179-5735","type":"print"},{"value":"1179-5735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"article-number":"11795735231195756"}}