{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:39:19Z","timestamp":1777516759753,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82301376"],"award-info":[{"award-number":["No.82301376"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report three cases of immediate brainstem hemorrhage following intravenous thrombolysis with tenecteplase (TNK) in patients with minor ischemic stroke, resulting in poor outcomes and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe the clinical characteristics, imaging findings, and outcomes of three patients who developed brainstem parenchymal hemorrhage immediately after TNK thrombolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All three patients had minor ischemic stroke (National Institute of Health stroke scale score \u22645) and presented with elevated blood pressure on admission. Blood pressure was lowered to guideline-recommended levels (&lt;180 mmHg) using intravenous antihypertensives before thrombolysis. Despite rapid brain protection measures, including hematoma evacuation or external ventricular drainage in two cases and conservative management in one, all patients died due to brainstem hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These cases suggest that fatal brainstem hemorrhage may occur after TNK thrombolysis in minor stroke. For patients with a history of poorly controlled hypertension, careful risk assessment and aggressive blood pressure management are critical if thrombolysis is considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795735251409050","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:04:56Z","timestamp":1767420296000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Immediate Brainstem Hemorrhage after Thrombolysis in Ischemic Stroke With Poorly Controlled Hypertension: Insights From Three Clinical Cases"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-5661","authenticated-orcid":false,"given":"Lei","family":"Shen","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niao","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan University of Science & Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Mei","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Yan","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012781"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00519-1"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.192535"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.644815"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010049"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70120-6"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.1.126"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.28123"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744802"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.727962"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/life13030846"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034580"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8496"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.14721"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01054-6"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.4.510"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000164098"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00292.2022"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283523e1c"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.09.007"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009318"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24760"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000196942.84707.71"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.048248"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735251409050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795735251409050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735251409050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:59:56Z","timestamp":1777391996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795735251409050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":26,"alternative-id":["10.1177\/11795735251409050"],"URL":"https:\/\/doi.org\/10.1177\/11795735251409050","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"value":"1179-5735","type":"print"},{"value":"1179-5735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"article-number":"11795735251409050"}}