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In this exploratory analysis, we draw on prospective observational trials using smartwatches in patients with multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and migraine, who were monitored for 6 to 24\u00a0months. Through detailed clinical case narratives, we illustrate both the potential and the limitations of RPM in neurology. Wearable-generated data successfully captured early, clinically meaningful changes, such as the onset of a myasthenic exacerbation, and supported patient engagement in identifying individual triggers, including for migraine. However, external influences such as holidays, infections, or mobility aid use confounded activity signals, underscoring the importance of contextual interpretation. While wearables can enhance neurological care, their integration into clinical workflows is challenged by limited validation and interpretability. Realising their potential requires robust validation in clinical settings and the development of interoperable RPM platforms supported by close collaboration between clinicians, engineers, and patients.<\/jats:p>","DOI":"10.1177\/11795735261419641","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:02:03Z","timestamp":1770811323000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case-Based Lessons on Remote Patient Monitoring in Neurology Using Consumer-Grade Wearables"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6219-988X","authenticated-orcid":false,"given":"Paula Z.","family":"Epping","sequence":"first","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Hagler","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah M.","family":"Werner","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Voth","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linea","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Potsdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Huntemann","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel D.","family":"Stern","sequence":"additional","affiliation":[{"name":"University of Potsdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ruck","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"},{"name":"Ruhr-University Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-2277","authenticated-orcid":false,"given":"Marc","family":"Pawlitzki","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Masanneck","sequence":"additional","affiliation":[{"name":"University Hospital and Medical Faculty University Hospital D\u00fcsseldorf"},{"name":"University of Potsdam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_3_8_2_2","unstructured":"FDA. 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