{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:31:11Z","timestamp":1788831071284,"version":"build-2803163510"},"reference-count":73,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FUBAP","award":["MF.18.51"],"award-info":[{"award-number":["MF.18.51"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomed Eng Comput Biol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    This study was aimed to coat a hybrid bioceramic composite onto Ti\n                    <jats:sub>6<\/jats:sub>\n                    Al\n                    <jats:sub>4<\/jats:sub>\n                    V by using hydrothermal method. The Hybrid bioceramic composite for coating was prepared by reinforcing different rations of expanded perlite (EP) and 5\u2009wt.% chitosan into synthesized Hydroxyapatite (HA). Coating was performed at 1800\u00b0C for 12\u2009hours. The coated specimens were gradually subjected to a sintering at 6000\u00b0C for 1\u2009hour. For in vitro analysis, the specimens were kept in Ringer\u2019s solution for 1, 10, and 25\u2009days. All specimens were examined by SEM, EDX, FTIR, and surface roughness analyses for characterizing. It was concluded that as the reinforcement ratio increased, there was an increase in coating thickness and surface roughness. The optimum reinforcement ratio for expanded perlite can be 10\u2009wt.% (A3-B3). With increasing ratio of calcium (Ca) and phosphate (P) (Ca\/P), the surface becomes more active in body fluid and then observed the formation of the hydroxycarbonate apatite (HCA) layer. As the waiting time increased, there was an increase in the formation of an apatite structure.\n                  <\/jats:p>","DOI":"10.1177\/11795972231151348","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:15:27Z","timestamp":1684138527000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hydroxyapatite-Bioceramic\/Expanded Perlite Hybrid Composites Coating on Ti\n                    <sub>6<\/sub>\n                    Al\n                    <sub>4<\/sub>\n                    V by Hydrothermal Method and in vitro Behavior"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-7869","authenticated-orcid":false,"given":"Mehtap","family":"Murato\u011flu","sequence":"first","affiliation":[{"name":"Department of Metallurgy and Materials Engineering, F\u0131rat University, Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011f\u00e7e","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Metallurgy and Materials Engineering, F\u0131rat University, Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"bibr1-11795972231151348","unstructured":"Von Recum AF. Handbook of Biomaterials Evolution. Macmillian; 1986. https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jab.770060209"},{"key":"bibr2-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1042\/BA20000052"},{"key":"bibr3-11795972231151348","volume-title":"Metallie Biomaterials, the Biomedical Engineering Handbook","author":"Park JB","year":"2000","edition":"2"},{"key":"bibr4-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2219(00)00129-1"},{"key":"bibr5-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56486-4"},{"key":"bibr6-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.033"},{"key":"bibr7-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2004.11.009"},{"key":"bibr8-11795972231151348","volume-title":"2nd International Advances in Applied Physics & Materials Science Congress, Antalya","author":"Yoruc ABH","year":"2012"},{"key":"bibr9-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-0584(03)00116-0"},{"key":"bibr10-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.01.055"},{"key":"bibr11-11795972231151348","first-page":"10","volume":"15","author":"Albayrak O","year":"2007","journal-title":"Rev Adv Mater Sci"},{"key":"bibr12-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00146-4"},{"key":"bibr13-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2011.03.103"},{"key":"bibr14-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2012.11.024"},{"key":"bibr15-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2015.01.019"},{"key":"bibr16-11795972231151348","volume-title":"Chemical Processing of Ceramics","author":"Somiya S","year":"2005","edition":"2"},{"key":"bibr17-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2006.01.012"},{"key":"bibr18-11795972231151348","unstructured":"Ilshin Autoclave. Supercritical Hydrothermal Synthesis. Eri\u015fim: 31 May\u0131s 2012."},{"key":"bibr19-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2003.12.120"},{"key":"bibr20-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1039\/b007852m"},{"key":"bibr21-11795972231151348","author":"Larry L","year":"1993","journal-title":"An Introduction to Bioceramics"},{"key":"bibr22-11795972231151348","first-page":"653","volume":"24","author":"Sinha A","year":"2001","journal-title":"Indian Acad Sci"},{"key":"bibr23-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.023"},{"key":"bibr24-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.03.041"},{"key":"bibr25-11795972231151348","first-page":"3","volume-title":"Applications of Chitin and Chitosan","author":"Li Q","year":"1997"},{"key":"bibr26-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3008-7"},{"key":"bibr27-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0728(99)00260-0"},{"key":"bibr28-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2016.02.193"},{"key":"bibr29-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.12.002"},{"key":"bibr30-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.10.057"},{"key":"bibr31-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2007.12.003"},{"key":"bibr32-11795972231151348","first-page":"1","volume":"7","author":"B\u00fcy\u00fcksa\u011fi\u015f A.","year":"2010","journal-title":"Makine Teknolojileri Elektronik Dergisi"},{"key":"bibr33-11795972231151348","unstructured":"https:\/\/en.perlit.com\/expanded-perlite"},{"key":"bibr34-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820050613"},{"key":"bibr35-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820271204"},{"key":"bibr36-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010977625309"},{"key":"bibr37-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.11.025"},{"key":"bibr38-11795972231151348","doi-asserted-by":"publisher","DOI":"10.12693\/APhysPolA.123.427"},{"key":"bibr39-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.062"},{"key":"bibr40-11795972231151348","first-page":"69","author":"Ba\u015fp\u0131nar MS","year":"2009","journal-title":"Afyon Kocatepe \u00dcniversitesi Fen Bilimleri Dergisi"},{"key":"bibr41-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.compscitech.2005.07.022"},{"key":"bibr42-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2016.03.127"},{"key":"bibr43-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1111\/j.1151-2916.1998.tb02301.x"},{"key":"bibr44-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-012-4598-2"},{"key":"bibr45-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2011.06.023"},{"key":"bibr46-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2014.06.054"},{"key":"bibr47-11795972231151348","first-page":"1","volume-title":"The Biomedical Engineering Handbook","author":"Park JB.","year":"2000","edition":"2"},{"key":"bibr48-11795972231151348","volume-title":"Biomaterials Science-An Introduction to Materials in Medicine","author":"Rather BD","year":"1996","edition":"2"},{"key":"bibr49-11795972231151348","first-page":"41","volume-title":"Biomaterials Science: An Introduction to Materials in Medicine","author":"Ratner BD.","year":"2012"},{"key":"bibr50-11795972231151348","unstructured":"Materials-for-biomedical applications. 2014. https:\/\/ocw.mit.edu\/courses\/3-051j-materials-for-biomedical-applications-spring"},{"key":"bibr51-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.04.023"},{"key":"bibr52-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/S0257-8972(99)00612-X"},{"key":"bibr53-11795972231151348","unstructured":"G\u00fcr AK, Ta\u015fk\u0131n M. Metalik Biyomalzemelerve Biyouyum. 2004;2:106-113."},{"key":"bibr54-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2008.08.017"},{"key":"bibr55-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1111\/j.1151-2916.1992.tb04470.x"},{"key":"bibr56-11795972231151348","unstructured":"http:\/\/acikerisim.baskent.edu.tr\/handle\/11727\/6688"},{"key":"bibr57-11795972231151348","first-page":"25","volume":"4","author":"Pasinli A.","year":"2004","journal-title":"Makine Teknolojileri Elektronik Dergisi"},{"key":"bibr58-11795972231151348","first-page":"187","volume":"13","author":"Hench LL","year":"1996","journal-title":"Life Chem Rep"},{"key":"bibr59-11795972231151348","author":"G\u00fcm\u00fc\u015fderelio\u011flu M.","year":"2002","journal-title":"Yeni Ufuklara: Biyomalzemeler"},{"key":"bibr60-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2005.12.126"},{"key":"bibr61-11795972231151348","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.264-268.1961"},{"key":"bibr62-11795972231151348","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.493-494.582"},{"key":"bibr63-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1111\/j.1551-2916.2007.01849.x"},{"key":"bibr64-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2008.04.003"},{"key":"bibr65-11795972231151348","volume-title":"Production of Hydroxylapatite from Animal Bone","author":"G\u00f6ren \u015e.","year":"2003"},{"key":"bibr66-11795972231151348","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.264-268.1949"},{"key":"bibr67-11795972231151348","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2004.11.070"},{"key":"bibr68-11795972231151348","volume-title":"Biomaterials: An Introduction","author":"Park J","year":"2007"},{"key":"bibr69-11795972231151348","volume-title":"Biomaterials Introduction to Biomedical Engineering","author":"Kuhn TL.","year":"2012","edition":"3"},{"key":"bibr70-11795972231151348","volume-title":"The Biomedical Engineering HandBook","author":"Parkh E","year":"2000","edition":"2"},{"key":"bibr71-11795972231151348","unstructured":"Teknoloji Haber Sitesi. Biyomalzemeler,Biyouyumluluk ve S\u0131n\u0131fland\u0131r\u0131lmas\u0131. 2011. https:\/\/dergipark.org.tr\/tr\/pub\/jesd\/issue\/20871\/223984"},{"key":"bibr72-11795972231151348","unstructured":"Erg\u00fcn Y, Ba\u015fpinar S, Taktak \u015e, Evcin A Titanyum Y\u00fczeyine Sol-Jel Y\u00f6ntemiyle Hidroksiapatit Kaplanmas\u0131 Afyon Kocatepe \u00dcniversitesi FenVe M\u00fchendislik Bilimleri Dergisi Ar\u015fiv Cilt 9, Say\u0131 3. 2009."},{"key":"bibr73-11795972231151348","first-page":"106","volume":"55","author":"Luti\u0161anov\u00e1 G","year":"2011","journal-title":"Ceramics \u2013 Silik\u00e1ty"}],"container-title":["Biomedical Engineering and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795972231151348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795972231151348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795972231151348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:59:06Z","timestamp":1777381146000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795972231151348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":73,"alternative-id":["10.1177\/11795972231151348"],"URL":"https:\/\/doi.org\/10.1177\/11795972231151348","relation":{},"ISSN":["1179-5972","1179-5972"],"issn-type":[{"value":"1179-5972","type":"print"},{"value":"1179-5972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"11795972231151348"}}