{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:06Z","timestamp":1787019126566,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Topical photodynamic therapy (PDT) mediated with 5-aminolevulinic acid (ALA) offers an alternative option for the treatment of acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To study the effects of ALA dose, incubation time, and lesion type on protoporphyrin IX (PpIX) production and treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      To examine the time course of PpIX production, 10% ALA was applied to inflammatory papules for 1 to 5 hours and followed by in situ fluorescence examination. To determine the effects of ALA dose and lesion type, 3, 5, and 10% ALA was applied to acne lesions in split-face fashion for 3 hours followed by whole-face light irradiation at 633 nm and 30 to 70 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Treatment was repeated twice at 2-week intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PpIX reached a stable level after 3 hours of incubation. Similar PpIX levels were seen in areas receiving 3, 5, and 10% ALA. Poisson regression analyses indicated that lesion counts decreased by 0.791 times for a one-unit increase in treatment times (95% CI 0.782\u20130.799, p&lt; .0001) but only by 0.999 times for a one-unit increase in ALA dose (95% CI 0.998\u20131.000, p = .22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The combination of low-dose ALA and a red light is a safe and effective option for the treatment of moderate to severe acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Renseignements de base:<\/jats:title>\n                    <jats:p>La th\u00e9rapie photodynamique topique (TPD) suivant l'administration de l'acide 5-aminol\u00e9vulinique (ALA) repr\u00e9sente une autre possibilit\u00e9 pour le traitement de l'acn\u00e9 vulgaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectif:<\/jats:title>\n                    <jats:p>\u00c9tudier les effets de la dose d'ALA, la dur\u00e9e d'incubation, le type de l\u00e9sion sur la production de PpIX, et les r\u00e9sultats du traitement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thodes:<\/jats:title>\n                    <jats:p>\n                      Pour examiner l'\u00e9volution temporelle de la production de PpIX, de l'ALA 10 % a \u00e9t\u00e9 appliqu\u00e9 sur des papules inflammatoires pendant 1 \u00e0 5 heures et a \u00e9t\u00e9 suivi d'un examen in situ en fluorescence. Afin de d\u00e9terminer les effets de la dose d'ALA et le type de l\u00e9sion, de l'ALA 3, 5, et 10 % a \u00e9t\u00e9 appliqu\u00e9 sur les l\u00e9sions d'acn\u00e9 sur une moiti\u00e9 du visage pendant 3 heures, suivi d'une irradiation de lumi\u00e8re de tout le visage \u00e0 633 nm et 30 \u00e0 70 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Le traitement a \u00e9t\u00e9 r\u00e9p\u00e9t\u00e9 deux fois \u00e0 2 semaines d'intervalle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats:<\/jats:title>\n                    <jats:p>La PpIX a atteint un niveau stable apr\u00e8s 3 heures d'incubation. Des taux de PpIX semblables ont \u00e9t\u00e9 observ\u00e9s dans les parties ayant re\u00e7u de l'ALA 3, 5, et 10 %. Des analyses de r\u00e9gression de Poisson ont indiqu\u00e9 que le nombre de l\u00e9sions a diminu\u00e9 de 0,791 fois pour une augmentation d'une unit\u00e9 de temps de traitement (IC 95 % 0,782 \u00e0 0,799, p &lt;,0001), mais seulement par 0,999 fois pour un accroissement d'une unit\u00e9 de dose d'ALA (CI 95 % 0,998 \u00e0 1,000, p =, 22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>La combinaison d'une faible dose d'ALA et de la lumi\u00e8re rouge est une option s\u00fbre et efficace pour traiter l'acn\u00e9 mod\u00e9r\u00e9e \u00e0 s\u00e9v\u00e8re.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600509","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:24:11Z","timestamp":1484043851000},"page":"324-333","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Prospective Study of Topical 5-Aminolevulinic Acid Photodynamic Therapy for the Treatment of Moderate to Severe Acne Vulgaris in Chinese Patients"],"prefix":"10.1177","volume":"16","author":[{"given":"Hong-Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Skin Diseases Hospital and Huadong Hospital, Shanghai, P. 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