{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:28:07Z","timestamp":1781011687327,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pemphigus vegetans is a rare variant of pemphigus vulgaris, comprising 1 to 2% of all pemphigus cases. Exposures to oral agents such as captopril and penicillamine and, less commonly, physical or chemical factors have been implicated in the development of pemphigus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We report a 42-year-old white male with a 12-month history of hypertrophic, vegetative plaques affecting primarily his external nares and upper lips. The patient had a history of alcoholism and intermittent drug abuse, primarily intranasal cocaine, since his youth. He had been using cocaine heavily three to four times\/week for 1 month prior to and 1 month following the onset of the eruption but has since ceased use. His clinical features and histopathologic findings were consistent with a diagnosis of pemphigus vegetans. Treatment with high-dose prednisone (80 mg\/d) and mycophenolate mofetil (1.5 g\/d) resulted in resolution of the lesions after 18 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusions:<\/jats:title>\n                    <jats:p>To our knowledge, this is the second report proposing an association between intranasal cocaine use and the pemphigus family of disorders. Although the relationship between illicit drug use and the development of pemphigus is unclear, we postulate that intranasal cocaine abuse is operative in our patient's disease. Herein we discuss drug and other external precipitants of pemphigus and review previous case reports of pemphigus associated with illicit drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Renseignements de base:<\/jats:title>\n                    <jats:p>Le pemphigus v\u00e9g\u00e9tant est une variante rare du pemphigus vulgaire, comptant pour 1 \u00e0 2 % de tous les cas de pemphigus. Un rapprochement a \u00e9t\u00e9 \u00e9tabli entre l'exposition \u00e0 des agents oraux tels que le captopril et la p\u00e9nicillamine et, moins couramment, \u00e0 des facteurs physiques ou chimiques, dans le d\u00e9veloppement du pemphigus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thodes:<\/jats:title>\n                    <jats:p>Nous exposons le cas d'un homme de race blanche \u00e2g\u00e9 de 42 ans ayant des ant\u00e9c\u00e9dents de plaques v\u00e9g\u00e9tatives hypertrophiques pendant 12 mois, touchant principalement ses narines externes et ses l\u00e8vres sup\u00e9rieures. Le patient avait des ant\u00e9c\u00e9dents d'alcoolisme et de consommation intermittente de drogues, principalement de la coca\u00efne prise par voie intranasale, depuis sa jeunesse. Il avait consomm\u00e9 de fa\u00e7on excessive de la coca\u00efne trois \u00e0 quatre fois par semaine pendant le mois qui avait pr\u00e9c\u00e9d\u00e9 et avait suivi l'apparition de l'\u00e9ruption, mais il a depuis ce temps cess\u00e9 d'en user. Ses caract\u00e9ristiques cliniques et les r\u00e9sultats histopathologiques correspondaient \u00e0 un diagnostic de pemphigus v\u00e9g\u00e9tant. Le traitement consistant en la prise de fortes doses de prednisone (80 mg\/j) et de mycophenolate mofetil (1,5 g\/j) a entra\u00een\u00e9 la r\u00e9sorption des l\u00e9sions apr\u00e8s 18 mois.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats et conclusions:<\/jats:title>\n                    <jats:p>\u00c0 notre connaissance, ce rapport est le deuxi\u00e8me qui propose l'existence d'une association entre la consommation de coca\u00efne par voie intranasale et le groupe de maladies pemphigus. Bien que la relation entre la consommation de drogues illicites et le d\u00e9veloppement du pemphigus ne soit pas claire, nous postulons que la consommation de coca\u00efne par voie intranasale a une incidence sur la maladie de notre patient. Nous discutons aux pr\u00e9sentes des drogues et d'autres d\u00e9clencheurs externes du pemphigus et nous examinons les rapports de cas ant\u00e9rieurs de pemphigus associ\u00e9 \u00e0 la consommation de drogues illicites.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600512","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:24:11Z","timestamp":1484043851000},"page":"344-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Pemphigus Vegetans Associated with Intranasal Cocaine Abuse"],"prefix":"10.1177","volume":"16","author":[{"given":"Jennifer T.","family":"Ngo","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology and Laboratory Medicine and the Division of Dermatology, University of Calgary, Calgary, AB."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Trotter","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology and Laboratory Medicine and the Division of Dermatology, University of Calgary, Calgary, AB."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne H.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology and Laboratory Medicine and the Division of Dermatology, University of Calgary, Calgary, AB."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr1-120347541201600512","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"bibr2-120347541201600512","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1984.tb05688.x"},{"key":"bibr3-120347541201600512","author":"Fitzpatrick TB","year":"2008","journal-title":"New York: McGraw-Hill;"},{"key":"bibr4-120347541201600512","doi-asserted-by":"publisher","DOI":"10.1007\/BF02317108"},{"key":"bibr5-120347541201600512","unstructured":"HallopeauH. 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