{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:38Z","timestamp":1777513658776,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lichen simplex chronicus is a common skin disorder characterized by circumscribed, lichenified, pruritic plaque secondary to local repetitive trauma, notably rubbing and scratching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We describe a case of a squamous cell carcinoma arising in a patient with a long-lasting history of lichen simplex chronicus and discuss the potential role of the microenvironment in predisposing the malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Here we propose a hypothesis in which rubbing and scratching contribute to an excess of inflammatory mediators, which in turn may lead to alterations in the processes of keratinocyte proliferation and differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Renseignements de base:<\/jats:title>\n                    <jats:p>Le lichen simplex chronique est une affection cutan\u00e9e courante caract\u00e9ris\u00e9e par une plaque pruritique lich\u00e9nifi\u00e9e circonscrite cons\u00e9cutive \u00e0 des traumatismes locaux r\u00e9p\u00e9t\u00e9s, notamment le frottement et le grattage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectif:<\/jats:title>\n                    <jats:p>Nous d\u00e9crivons un cas de carcinome squameux chez un patient pr\u00e9sentant depuis longtemps des ant\u00e9c\u00e9dents de lichen simplex chronique, et nous discutons du r\u00f4le potentiel du micro-environnement dans la pr\u00e9disposition de la transformation maligne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nous proposons ici une hypoth\u00e8se selon laquelle le frottement et le grattage contribuent \u00e0 un exc\u00e8s de m\u00e9diateurs inflammatoires, lesquels peuvent \u00e0 leur tour venir modifier les processus de prolif\u00e9ration et de diff\u00e9renciation des k\u00e9ratinocytes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600513","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:24:11Z","timestamp":1484043851000},"page":"350-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Occurrence of Squamous Cell Carcinoma in an Area of Lichen Simplex Chronicus: Case Report and Pathogenetic Hypothesis"],"prefix":"10.1177","volume":"16","author":[{"given":"Cesare","family":"Tiengo","sequence":"first","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Deluca","sequence":"additional","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Belloni-Fortina","sequence":"additional","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Salmaso","sequence":"additional","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Galifi","sequence":"additional","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Alaibac","sequence":"additional","affiliation":[{"name":"Units of Plastic Surgery, Dermatology, and Pathology, University of Padua, Padua, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr1-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00168.x"},{"key":"bibr2-120347541201600513","unstructured":"Lichen simplex chronicus, In: WolffK, JohnsonAR, SuurmondR, Editors. Fitzpatrick's color atlas and synopsis of clinical dermatology: common and serious diseases. 6th ed. New York: McGraw-Hill; 1997. p. 42-3."},{"key":"bibr3-120347541201600513","unstructured":"HoganDJ, MasonSH, BowerSM. Lichen simplex chronicus. Available at: http:\/\/emedicine.medscape.com\/article\/1123423-overview."},{"key":"bibr4-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200406000-00001"},{"key":"bibr5-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00244.x"},{"key":"bibr6-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28553"},{"key":"bibr7-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.08.021"},{"key":"bibr8-120347541201600513","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.01.001"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347541201600513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347541201600513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:25Z","timestamp":1777391365000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/120347541201600513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/120347541201600513"],"URL":"https:\/\/doi.org\/10.1177\/120347541201600513","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}