{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:43Z","timestamp":1777513663931,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psoriasis is a relatively common inflammatory disease of the skin and joints. Moderate to severe psoriasis often necessitates lifelong alternating systemic therapies, many of which may increase the risk of nonmelanoma skin cancers and lymphoproliferative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>A 34-year-old male was diagnosed with squamous cell carcinoma (SCC) involving the right lower bulbar and palpebral conjunctiva with extension to the proximal lacrimal drainage system. The patient had suffered from severe psoriasis since childhood, for which he was on long-standing systemic cyclosporine, topical tacrolimus, and previous phototherapy. Margin-controlled excision of the lower half of the bulbar conjunctiva and lower eyelid with subsequent reconstruction was performed, followed by adjunctive topical mitomycin C 0.04% drops and local interferon injections. Cyclosporine was replaced with oral prednisolone. The patient was free of recurrence of SCC at 18 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although conjunctival SCC has been described following cyclosporine treatment for organ transplantation, this report describes a case of conjunctival SCC following lower-dose cyclosporine treatment for psoriasis in a patient who had previous psoralen plus ultraviolet A (PUVA) treatment. The conjunctival SCC should be considered in the differential diagnosis of new conjunctival lesions in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Renseignements de base:<\/jats:title>\n                    <jats:p>Le psoriasis est une affection inflammatoire relativement courante de la peau et des articulations. La forme mod\u00e9r\u00e9e \u00e0 grave du psoriasis n\u00e9cessite souvent le recours \u00e0 des traitements syst\u00e9miques altern\u00e9s permanents, dont bon nombre peuvent augmenter le risque de cancers de la peau sans m\u00e9lanome et de troubles lymphoprolif\u00e9ratifs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Description de cas:<\/jats:title>\n                    <jats:p>On a diagnostiqu\u00e9, chez un homme \u00e2g\u00e9 de 34 ans, un carcinome spinocellulaire (CSC) touchant la conjonctive bulbaire palp\u00e9brale inf\u00e9rieure droite et s'\u00e9tendant au syst\u00e8me de drainage lacrymal proximal. Le patient souffrait d'une forme grave de psoriasis depuis son enfance et suivait depuis longtemps un traitement syst\u00e9mique par la cyclosporine et le tacrolimus topique, ainsi qu'un traitement de phototh\u00e9rapie ant\u00e9rieur. Une excision avec contr\u00f4le de la marge sur la moiti\u00e9 inf\u00e9rieure de la conjonctive bulbaire et de la paupi\u00e8re inf\u00e9rieure avec reconstruction subs\u00e9quente a \u00e9t\u00e9 effectu\u00e9e, suivie d'un traitement topique par la mitomycine C en collyre \u00e0 0,04% et des injections locales d'interf\u00e9rons. La cyclosporine a \u00e9t\u00e9 remplac\u00e9e par la prednisolone administr\u00e9e par voie orale. Le patient demeure sans r\u00e9cidive de CSC \u00e0 18 mois.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bien que le CSC conjonctival ait \u00e9t\u00e9 d\u00e9crit suivant le traitement par la cyclosporine pour la transplantation d'organe, ce rapport d\u00e9crit un cas de CSC conjonctival survenu \u00e0 la suite d'un traitement \u00e0 faible dose par la cyclosporine pour le psoriasis chez un patient ayant suivi un traitement PUVA-th\u00e9rapeutique ant\u00e9rieur. Le CSC conjonctival doit \u00eatre consid\u00e9r\u00e9 dans le diagnostic diff\u00e9rentiel des nouvelles l\u00e9sions conjonctivales chez de tels patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600517","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:24:11Z","timestamp":1484043851000},"page":"365-367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Conjunctival Squamous Cell Carcinoma following Psoriasis Treatment"],"prefix":"10.1177","volume":"16","author":[{"given":"Radwan","family":"Almousa","sequence":"first","affiliation":[{"name":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK, and the Department of Ophthalmology, Mayday University Hospital, Purley, Surrey, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheraz","family":"Daya","sequence":"additional","affiliation":[{"name":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK, and the Department of Ophthalmology, Mayday University Hospital, Purley, Surrey, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Lake","sequence":"additional","affiliation":[{"name":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK, and the Department of Ophthalmology, Mayday University Hospital, Purley, Surrey, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Richardson","sequence":"additional","affiliation":[{"name":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK, and the Department of Ophthalmology, Mayday University Hospital, Purley, Surrey, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK, and the Department of Ophthalmology, Mayday University Hospital, Purley, Surrey, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"bibr1-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"key":"bibr2-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.031"},{"key":"bibr3-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(89)80010-1"},{"key":"bibr4-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1159\/000018142"},{"key":"bibr5-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12040.x"},{"key":"bibr6-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.031120"},{"key":"bibr7-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199909000-00005"},{"key":"bibr8-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.17.1278"},{"key":"bibr9-120347541201600517","first-page":"94","volume":"40","author":"Soker S","year":"2008","journal-title":"Ann Ophthalmol"},{"key":"bibr10-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-7"},{"key":"bibr11-120347541201600517","author":"Norman KG","journal-title":"Mitochondrion"},{"key":"bibr12-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199907000-00018"},{"key":"bibr13-120347541201600517","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06315.x"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347541201600517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347541201600517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:26Z","timestamp":1777391366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/120347541201600517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/120347541201600517"],"URL":"https:\/\/doi.org\/10.1177\/120347541201600517","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}