{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:58Z","timestamp":1777513678297,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Muir-Torre syndrome (MTS) is a rare genodermatosis considered a subtype of hereditary nonpolyposis colorectal cancer and traditionally associated with mutations in the mismatch repair genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We describe a 51-year-old male with primary manifestations of recurrent sebaceous adenoma of the upper eyelid, a positive cancer family history, and metachronous occurrence of colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>The diagnosis of MTS was established based on the clinical course, family history, and histopathologic findings, although further immunohistologic testing revealed the absence of MSH2 mutation. We additionally performed an updated summary of published MTS cases with sebaceous neoplasms originating from the eyelid and conjunctiva for the period 2005 to 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This patient, the second Greek case described in the international literature, is of interest mainly because of the metachronous occurrence of the visceral malignancy in combination with the absence of MSH2 mutation. The need for high clinical suspicion for MTS in cases with sebaceous lesions of the periocular region should therefore be reinforced regardless of the mutational screening test undertaken.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Contexte:<\/jats:title>\n                    <jats:p>Le syndrome de Muir-Torre (SMT) est une g\u00e9nodermatose rare, consid\u00e9r\u00e9e comme un sous-type du cancer colorectal h\u00e9r\u00e9ditaire, non polyposique, et habituellement associ\u00e9e \u00e0 des mutations des g\u00e8nes de r\u00e9paration des m\u00e9sappariements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectif:<\/jats:title>\n                    <jats:p>Nous faisons \u00e9tat ici du cas d'un homme de 51 ans, pr\u00e9sentant l'accumulation de faits suivants: manifestations primaires d'ad\u00e9nome s\u00e9bac\u00e9 r\u00e9cidivant de la paupi\u00e8re sup\u00e9rieure, ant\u00e9c\u00e9dents familiaux de cancer, et apparition asynchrone d'un cancer colorectal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thode:<\/jats:title>\n                    <jats:p>Le diagnostic de SMT a \u00e9t\u00e9 pos\u00e9 \u00e0 partir de l'\u00e9volution clinique, des ant\u00e9c\u00e9dents familiaux, et de l'examen histopathologique, bien que les analyses immunohistologiques ult\u00e9rieures aient r\u00e9v\u00e9l\u00e9 l'absence de mutation du g\u00e8ne MSH2. Nous avons \u00e9galement proc\u00e9d\u00e9 \u00e0 la mise \u00e0 jour d'un r\u00e9sum\u00e9 de cas publi\u00e9s de SMT, accompagn\u00e9 de n\u00e9oplasmes s\u00e9bac\u00e9s prenant naissance dans la paupi\u00e8re et la conjonctive, qui se sont produits durant la p\u00e9riode de 2005 \u00e0 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ce qui fait surtout l'int\u00e9r\u00eat du pr\u00e9sent cas, le deuxi\u00e8me cas grec d\u00e9crit dans la documentation internationale, est l'apparition asynchrone d'un cancer des visc\u00e8res malgr\u00e9 l'absence de mutation du g\u00e8ne MSH2. Ce cas vient donc renforcer la n\u00e9cessit\u00e9 d'avoir constamment \u00e0 l'esprit la possibilit\u00e9 de SMT dans les cas de l\u00e9sions s\u00e9bac\u00e9es dans la r\u00e9gion p\u00e9rioculaire, et ce, ind\u00e9pendamment du test de d\u00e9pistage de mutations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600607","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T08:24:48Z","timestamp":1484468688000},"page":"394-399","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Metachronous Occurrence of Colorectal Cancer in a Muir-Torre Syndrome Patient Presenting with Recurrent Sebaceous Adenoma of the Eyelid: Case Report and Updated Review of the Literature"],"prefix":"10.1177","volume":"16","author":[{"given":"Christos","family":"Agiannidis","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Theagenio Cancer Hospital, Thessaloniki, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe D.","family":"Pana","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Theagenio Cancer Hospital, Thessaloniki, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Molyva","sequence":"additional","affiliation":[{"name":"2nd Pediatric Department, Unit of Pediatric Hematology Oncology, AHEPA University Hospital, Thessaloniki, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kalokasidis","sequence":"additional","affiliation":[{"name":"2nd Pediatric Department, Unit of Pediatric Hematology Oncology, AHEPA University Hospital, Thessaloniki, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Mixiou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"bibr1-120347541201600607","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6448-9_17"},{"key":"bibr2-120347541201600607","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03454.x"},{"key":"bibr3-120347541201600607","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-008-9183-y"},{"key":"bibr4-120347541201600607","doi-asserted-by":"crossref","unstructured":"CohenPR, KohnSR, DavisDA, KurzrockR. 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