{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:59Z","timestamp":1777513679444,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nerve involvement developed in a patient with granuloma annulare, as evidenced by a perineural infiltrate of histiocytes in the dermis. The histopathologic pattern was suggestive of leprosy. No mycobacteria were observed, and neurologic testing was normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether inflammation of the nerves or perineural tissue is common in granuloma annulare, we studied the cutaneous nerves in skin biopsy specimens from 14 patients with granuloma annulare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sections were stained with hematoxylin-eosin to highlight inflammatory cells and with S-100 to identify cutaneous nerves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No inflammation around nerves was found in 12 specimens, abutting granulomatous inflammation was found in 1 specimen, and enveloping granulomatous inflammation was found in 1 specimen. No nerves were infiltrated by inflammatory cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Perineural granulomatous inflammation resembling the perineural infiltrate of leprosy appears to be an uncommon characteristic of granuloma annulare. Clinical correlation and acid-fast stains can assist in establishing the correct diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Contexte:<\/jats:title>\n                    <jats:p>Une atteinte nerveuse est apparue chez un patient atteint de granulome annulaire, comme en t\u00e9moignait un infiltrat p\u00e9rineural d'histiocytes dans le derme. Les signes histopathologiques \u00e9taient \u00e9vocateurs de la l\u00e8pre, mais aucune mycobact\u00e9rie n'a \u00e9t\u00e9 observ\u00e9e, et l'examen neurologique \u00e9tait normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectif:<\/jats:title>\n                    <jats:p>L'\u00e9tude visait \u00e0 d\u00e9terminer si l'inflammation des nerfs ou du tissu p\u00e9rineural est fr\u00e9quente dans le granulome annulaire; pour ce faire, nous avons examin\u00e9 les nerfs cutan\u00e9s dans des pr\u00e9l\u00e8vements biopsiques de la peau, effectu\u00e9s sur 14 patients atteints de granulome annulaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thodes:<\/jats:title>\n                    <jats:p>Les coupes ont \u00e9t\u00e9 color\u00e9es \u00e0 l'h\u00e9matoxyline-\u00e9osine pour mettre en \u00e9vidence des cellules inflammatoires, ainsi qu'au S-100 pour rep\u00e9rer les nerfs cutan\u00e9s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats:<\/jats:title>\n                    <jats:p>Aucune inflammation autour des nerfs n'a \u00e9t\u00e9 observ\u00e9e sur 12 pr\u00e9l\u00e8vements, mais il y avait pr\u00e9sence d'inflammation granulomateuse contigu\u00eb sur un pr\u00e9l\u00e8vement et d'inflammation granulomateuse enveloppante, sur un autre pr\u00e9l\u00e8vement. Les nerfs n'ont pas \u00e9t\u00e9 infiltr\u00e9s par les cellules inflammatoires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>L'inflammation granulomateuse p\u00e9rineurale qui ressemble \u00e0 l'infiltration p\u00e9rineurale observ\u00e9e dans la l\u00e8pre semble un signe peu fr\u00e9quent du granulome annulaire. L'\u00e9tablissement de corr\u00e9lations cliniques et des colorations r\u00e9sistantes \u00e0 l'acide peuvent faciliter la pose du bon diagnostic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600612","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T08:24:48Z","timestamp":1484468688000},"page":"428-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Nerve Involvement in Granuloma Annulare"],"prefix":"10.1177","volume":"16","author":[{"given":"Michelle","family":"Longmire","sequence":"first","affiliation":[{"name":"Medical student, College of Medicine, Mayo Clinic, Rochester, MN. She is now with the Department of Dermatology, Stanford University, Palo Alto, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Dicaudo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, AZ, and the College of Medicine, Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark V.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, AZ, and the College of Medicine, Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"bibr1-120347541201600612","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80181-2"},{"key":"bibr2-120347541201600612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00457.x"},{"key":"bibr3-120347541201600612","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.11.018"},{"key":"bibr4-120347541201600612","unstructured":"World Health Organization. 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Int J Lepr Other Mycobact Dis 1966;34:255\u201373."},{"key":"bibr12-120347541201600612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14123.x"},{"key":"bibr13-120347541201600612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00508.x"},{"key":"bibr14-120347541201600612","doi-asserted-by":"crossref","unstructured":"MaccormacH. Sarcoid of the hand resembling granuloma annulare. 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