{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:55:14Z","timestamp":1790013314901,"version":"4.0.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Granulomatous rosacea is considered a clinical variant of rosacea and is characterized by hard yellow, brown, red or flesh-colored cutaneous papules or nodules that may be severe and may lead to scarring. The lesions typically appear on the cheeks and periorificial lesions; they are monomorphic in each patient and sit on relatively normal-appearing skin. The diagnosis should be established by excluding other granulomatous disorders and rosacea-like eruptions such as sarcoidosis, tuberculosis, and lupus miliaris disseminatus faciei. The clinical course is chronic and unpredictable, and management can be very difficult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>We report the case of a 28-year-old female with granulomatous rosacea who responded successfully to oral isotretinoin. No recurrence was noticed 6 months after the completion of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Renseignements de base:<\/jats:title>\n                    <jats:p>La rosac\u00e9e granulomateuse est consid\u00e9r\u00e9e comme une variante clinique de la rosac\u00e9e et est caract\u00e9ris\u00e9e par la pr\u00e9sence de papules cutan\u00e9es jaunes, brunes, ou fleshed-colored rouges dures ou par de nodules qui peuvent \u00eatre graves et qui peuvent causer des cicatrices. Les l\u00e9sions sont g\u00e9n\u00e9ralement localis\u00e9es aux joues et sur les l\u00e9sions p\u00e9ri-orificielles; elles sont monomorphes chez chaque patient individuel et elles si\u00e8gent sur une peau d'apparence relativement normale. Le diagnostic doit \u00eatre \u00e9tabli en excluant les autres troubles granulomateux et les \u00e9ruptions rosac\u00e9iformes comme la sarco\u00efdose, la tuberculose, et la tuberculide papulonodulaire. L'\u00e9volution clinique est chronique et impr\u00e9visible, et la gestion peut \u00eatre tr\u00e8s difficile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Rapport de cas:<\/jats:title>\n                    <jats:p>Nous rapportons le cas d'une femme \u00e2g\u00e9e de 28 ans pr\u00e9sentant une rosac\u00e9e granulomateuse qui a \u00e9t\u00e9 trait\u00e9 avec succ\u00e8s avec l'isotr\u00e9tino\u00efne administr\u00e9e par voie orale. Aucune r\u00e9cidive n'a \u00e9t\u00e9 observ\u00e9e 6 mois apr\u00e8s la fin du traitement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600615","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T08:24:48Z","timestamp":1484468688000},"page":"438-441","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Isotretinoin for the Treatment of Granulomatous Rosacea: Case Report and Review of the Literature"],"prefix":"10.1177","volume":"16","author":[{"given":"Efstathios","family":"Rallis","sequence":"first","affiliation":[{"name":"Department of Dermatology, Veterans Administration Hospital (NIMTS), Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysovalantis","family":"Korfitis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Veterans Administration Hospital (NIMTS), Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"bibr1-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"bibr2-120347541201600615","unstructured":"Kupiec-BanasikowskaA, SinghS. Rosacea. Available at: http:\/\/emedicine.medscape.com\/article\/1071429 (accessed August 16, 2011)."},{"key":"bibr3-120347541201600615","unstructured":"DarierMJ. Les tuberculides cutan\u00e9es. Ann Dermatol Syph 1896;7:1431\u20136."},{"key":"bibr4-120347541201600615","unstructured":"LewandowskyF. \u00dcber Rosacea-\u00e4hnliche Tuberkulide des Geschites. Corr Bl Schweiz \u00c4rzte 1917;47:1280\u20132."},{"key":"bibr5-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1958.01560120001001"},{"key":"bibr6-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1940.01490160085012"},{"key":"bibr7-120347541201600615","unstructured":"ScottKW, CalnanCD. Acne agminata. Trans St Johns Hosp Dermatol Soc 1967;50:60\u20139."},{"key":"bibr8-120347541201600615","doi-asserted-by":"crossref","unstructured":"SnappRH. Lewandowsky's rosacea-like eruption: a clinical study. J Invest Dermatol 1949;13:175\u201389.","DOI":"10.1038\/jid.1949.86"},{"key":"bibr9-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1159\/000255660"},{"key":"bibr10-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1970.04000020076011"},{"key":"bibr11-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02063.x"},{"key":"bibr12-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1159\/000051539"},{"key":"bibr13-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1984.tb04206.x"},{"key":"bibr14-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70304-K"},{"key":"bibr15-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)80038-5"},{"key":"bibr16-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1159\/000068457"},{"key":"bibr17-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1159\/000246165"},{"key":"bibr18-120347541201600615","unstructured":"NikolowskiJ, PlewigG. Rosacea: Orale Behandlung mit 13-cis-Retins\u00e4ure. Hautarzt 1980;31:660\u20131."},{"key":"bibr19-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70067-2"},{"key":"bibr20-120347541201600615","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1984.tb00842.x"},{"key":"bibr21-120347541201600615","doi-asserted-by":"crossref","unstructured":"SchmidtJB, GebhartW, RaffM, SponaJ. 13-Cis-retinoic acid in rosacea. Clinical and laboratory findings. 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Hautarzt 2011 Oct 22. [Epub ahead of print]","DOI":"10.1007\/s00105-011-2144-7"},{"key":"bibr30-120347541201600615","unstructured":"SmithKW. Perioral dermatitis with histopathologic features of granulomatous rosacea: successful treatment with isotretinoin. 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