{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:48:09Z","timestamp":1777513689509,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report the efficacy of using topical tacrolimus in treating UNL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Topical tacrolimus was used in the treatment of two patients with UNL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>Topical tacrolimus is effective in treating UNL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Topical tacrolimus is a reasonably effective choice in treating UNL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Contexte:<\/jats:title>\n                    <jats:p>La n\u00e9crobiose lipo\u00efdique ulc\u00e9r\u00e9e (NLU) est une maladie rare, qui est souvent r\u00e9fractaire au traitement. Elle se caract\u00e9rise par des placards ulc\u00e9r\u00e9s et bien d\u00e9finis, des bords indur\u00e9s et des centres atrophiques. Diff\u00e9rentes formes de traitement ont \u00e9t\u00e9 utilis\u00e9es et se sont sold\u00e9es par des taux variables de r\u00e9ussite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectif:<\/jats:title>\n                    <jats:p>L'\u00e9tude visait \u00e0 faire \u00e9tat de l'efficacit\u00e9 du tacrolimus topique dans le traitement de la NLU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thode:<\/jats:title>\n                    <jats:p>Nous avons fait usage de tacrolimus topique dans le traitement de la NLU chez deux patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultat:<\/jats:title>\n                    <jats:p>Le tacrolimus topique s'est montr\u00e9 efficace dans le traitement de la NLU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Le tacrolimus topique est un moyen relativement efficace de traitement de la NLU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347541201600621","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T08:24:48Z","timestamp":1484468688000},"page":"458-461","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of Ulcerative Necrobiosis Lipoidica with Topical Calcineurin Inhibitor: Case Report and Literature Review"],"prefix":"10.1177","volume":"16","author":[{"given":"Yousef","family":"Binamer","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Toronto, Toronto, ON, and the Division of Dermatology, McGill University, Montreal, QC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sowerby","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Toronto, Toronto, ON, and the Division of Dermatology, McGill University, Montreal, QC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"El-Helou","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Toronto, Toronto, ON, and the Division of Dermatology, McGill University, Montreal, QC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"bibr1-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1007\/BF02071265"},{"key":"bibr2-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600210008002"},{"key":"bibr3-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.01.018"},{"key":"bibr4-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.1.20"},{"key":"bibr5-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80961-9"},{"key":"bibr6-120347541201600621","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04856.x"},{"key":"bibr7-120347541201600621","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506040-00003"},{"key":"bibr8-120347541201600621","doi-asserted-by":"crossref","unstructured":"HammamiH, YoussefS, JaberK. 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