{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:06:35Z","timestamp":1777514795664,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Histone deactylases (HDAC) have a role in the pathogenesis of mycosis fungoides (MF) through their actions on different apoptosis pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the possible role played by HDAC-2 in MF by estimating the tissue expression of HDAC2 mRNA in different stages of MF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included 28 MF patients and 30 controls. The HDAC-2 levels were detected by real-time polymerase chain reaction (PCR). Correlations of HDAC-2 levels with clinical presentation and different stages of MF were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean HDAC-2 level was significantly higher in patients ( P &lt; .001) than in controls. HDAC-2 highest mean value was significantly detected in patients with stage IIb, and the lowest mean value was detected in patients with stage Ia ( P &lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Up-regulation of tissue HDAC-2 in MF patients might develop a new approach in the understanding of the pathogenesis of MF. Histone deactylases are important targets for molecular cancer therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475415589055","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T23:21:11Z","timestamp":1433200871000},"page":"40-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Tissue Level of Histone Deactylase-2 (HDAC-2) in Patients With Mycosis Fungoides"],"prefix":"10.1177","volume":"20","author":[{"given":"Amira","family":"El Tawdy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Amin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Abdel Hay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Rashed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeiad","family":"Gad","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"bibr1-1203475415589055","first-page":"71","volume":"16","author":"Wong HK","year":"2013","journal-title":"Dicov Med"},{"key":"bibr2-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(99)80006-9"},{"key":"bibr3-1203475415589055","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786242796"},{"key":"bibr4-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm_04.x"},{"key":"bibr5-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001621588"},{"key":"bibr6-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2005.12.006"},{"key":"bibr7-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04523.x"},{"key":"bibr8-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.243"},{"key":"bibr9-1203475415589055","first-page":"1","volume":"6","author":"Poligone B","year":"2011","journal-title":"Core Evid"},{"key":"bibr10-1203475415589055","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2007-03-055749","volume":"110","author":"Olsen E","year":"2007","journal-title":"Blood"},{"key":"bibr11-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"bibr12-1203475415589055","first-page":"37","volume":"2","author":"Jain S","year":"2011","journal-title":"Blood Med"},{"key":"bibr13-1203475415589055","first-page":"285","volume":"3","author":"Bi G","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"bibr14-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1007\/s13148-010-0012-4"},{"key":"bibr15-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01009.x"},{"key":"bibr16-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1779"},{"key":"bibr17-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.01.002"},{"key":"bibr18-1203475415589055","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.11.002"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415589055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475415589055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415589055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:53:17Z","timestamp":1777391597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475415589055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1177\/1203475415589055"],"URL":"https:\/\/doi.org\/10.1177\/1203475415589055","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}