{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:53:08Z","timestamp":1778748788388,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Topical retinoids are first-line treatment options for acne vulgaris. These drugs, however, produce varying degree of cutaneous irritation within the first few weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our purpose was to examine differences in tolerability of topical retinoids and assess whether these differences would be clinically meaningful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A PubMed search was performed for sources on topical retinoids in acne vulgaris treatment. Thirty-four clinical studies were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirteen studies had statistically significant results on tolerability of retinoid based on retinoid, vehicle, concentration, or skin type. All studies classified most of skin reactions as mild-moderate. Large differences in the number of dropouts due to irritation were not identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Irritation studies did not show a high frequency of clinically significant irritation with topical retinoids. We anticipate that the large variation in patient use of topical retinoids would likely account for more variation in response than differences between drug formulations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475415591117","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:49:18Z","timestamp":1435020558000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Tolerability of Topical Retinoids"],"prefix":"10.1177","volume":"19","author":[{"given":"Leonora","family":"Culp","sequence":"first","affiliation":[{"name":"Center for Dermatology Research, Departments of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Moradi Tuchayi","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Departments of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Alinia","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Departments of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Departments of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"},{"name":"Departments of Pathology and Wake Forest School of Medicine, Winston-Salem, NC, USA"},{"name":"Departments of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"issue":"5","key":"bibr1-1203475415591117","first-page":"549","volume":"9","author":"Tanghetti E","year":"2010","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr2-1203475415591117","first-page":"625","volume":"6","author":"Campbell JL","year":"2007","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr3-1203475415591117","first-page":"632","volume":"6","author":"Dosik JS","year":"2007","journal-title":"J Drugs Dermatol"},{"issue":"4","key":"bibr4-1203475415591117","first-page":"383","volume":"8","author":"Leyden J","year":"2009","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr5-1203475415591117","first-page":"641","volume":"3","author":"Leyden J","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"bibr6-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1080\/09546630902763164"},{"key":"bibr7-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12013"},{"issue":"8","key":"bibr8-1203475415591117","first-page":"998","volume":"9","author":"Leyden JJ","year":"2010","journal-title":"J Drugs Dermatol"},{"issue":"9","key":"bibr9-1203475415591117","first-page":"1104","volume":"11","author":"Schorr ES","year":"2012","journal-title":"J Drugs Dermatol"},{"issue":"7","key":"bibr10-1203475415591117","first-page":"650","volume":"8","author":"Kircik LH","year":"2009","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr11-1203475415591117","first-page":"607","volume":"6","author":"Schlessinger J","year":"2007","journal-title":"J Drugs Dermatol"},{"issue":"4","key":"bibr12-1203475415591117","first-page":"438","volume":"12","author":"Feldman SR","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"bibr13-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.09.012"},{"issue":"3","key":"bibr14-1203475415591117","first-page":"136","volume":"10","author":"Herndon JH","year":"2012","journal-title":"Skinmed"},{"issue":"6","key":"bibr15-1203475415591117","first-page":"639","volume":"9","author":"Eichenfield LF","year":"2010","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr16-1203475415591117","first-page":"644","volume":"12","author":"Grove G","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"bibr17-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.06.021"},{"issue":"6","key":"bibr18-1203475415591117","first-page":"s18","volume":"7","author":"Pariser D","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"bibr19-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08308.x"},{"issue":"2","key":"bibr20-1203475415591117","first-page":"99","volume":"91","author":"Dhawan SS","year":"2013","journal-title":"Cutis"},{"key":"bibr21-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410021702"},{"key":"bibr22-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.046"},{"key":"bibr23-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2005.tb00739.x"},{"key":"bibr24-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01811.x"},{"issue":"6","key":"bibr25-1203475415591117","first-page":"714","volume":"11","author":"Guerra-Tapia A","year":"2012","journal-title":"J Drugs Dermatol"},{"issue":"3","key":"bibr26-1203475415591117","first-page":"318","volume":"11","author":"Jarratt MT","year":"2012","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr27-1203475415591117","first-page":"305","volume":"87","author":"Lucky AW","year":"2011","journal-title":"Cutis"},{"issue":"2","key":"bibr28-1203475415591117","first-page":"131","volume":"9","author":"Jackson JM","year":"2010","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"bibr29-1203475415591117","first-page":"611","volume":"12","author":"Eichenfield LF","year":"2013","journal-title":"J Drugs Dermatol"},{"issue":"5","key":"bibr30-1203475415591117","first-page":"524","volume":"18","author":"Loesche C","year":"2008","journal-title":"Eur J Dermatol"},{"key":"bibr31-1203475415591117","first-page":"s3","volume":"7","author":"Thiboutot D","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"bibr32-1203475415591117","doi-asserted-by":"publisher","DOI":"10.5070\/D30N81Z2H4"},{"issue":"2","key":"bibr33-1203475415591117","first-page":"153","volume":"4","author":"Shalita A","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"bibr34-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.879"},{"key":"bibr35-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04416.x"},{"key":"bibr36-1203475415591117","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0016-x"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415591117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475415591117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415591117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:53:17Z","timestamp":1777391597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475415591117"}},"subtitle":["Are There Clinically Meaningful Differences Among Topical Retinoids?"],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1177\/1203475415591117"],"URL":"https:\/\/doi.org\/10.1177\/1203475415591117","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}