{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:07:32Z","timestamp":1777514852267,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Primary immunodeficiency disorders, such as ataxia-telangiectasia (A-T), may rarely be associated with cutaneous granulomas without an identifiable infection. The authors report a case of a 3-year-old boy with A-T who presented with two persistent ulcerated erythematous nodules. Histopathology was consistent with a granulomatous process secondary to A-T, without an infectious origin. Partial improvement was noted with clobetasol propionate 0.05% cream applied twice daily under occlusion. Of note, the presence of multiple noninfectious granulomas in a child may be the initial sign of an immune deficiency and should alert the astute clinician to investigate for an underlying primary immunodeficiency. Herein, the authors discuss the associations of noninfectious granulomas and primary immunodeficiency disorders and present management options for these difficult-to-treat lesions.<\/jats:p>","DOI":"10.1177\/1203475415626085","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T21:29:57Z","timestamp":1451942997000},"page":"259-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Noninfectious Granulomas"],"prefix":"10.1177","volume":"20","author":[{"given":"Ilya","family":"Shoimer","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Immunology, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Haber","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"bibr1-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456897"},{"key":"bibr2-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-29"},{"key":"bibr3-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1145"},{"key":"bibr4-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02432.x"},{"key":"bibr5-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01140.x"},{"key":"bibr6-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83043-4"},{"key":"bibr7-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06619.x"},{"key":"bibr8-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1986.tb00537.x"},{"key":"bibr9-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(09)80245-4"},{"key":"bibr10-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00854.x"},{"key":"bibr11-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1159\/000330335"},{"key":"bibr12-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.060"},{"issue":"8","key":"bibr13-1203475415626085","first-page":"608","volume":"126","author":"Corbisier A","year":"1999","journal-title":"Ann Dermatol Venereol"},{"key":"bibr14-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1159\/000246117"},{"key":"bibr15-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02251.x"},{"key":"bibr16-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12765"},{"key":"bibr17-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000112"},{"key":"bibr18-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1159\/000018093"},{"key":"bibr19-1203475415626085","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70097-L"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415626085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475415626085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475415626085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:53:25Z","timestamp":1777391605000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475415626085"}},"subtitle":["A Sign of an Underlying Immunodeficiency?"],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/1203475415626085"],"URL":"https:\/\/doi.org\/10.1177\/1203475415626085","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}