{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:07:39Z","timestamp":1777514859197,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Background:<\/jats:title>\n Reed\u2019s syndrome, also known as hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome, is an autosomal dominant condition in which affected individuals may develop cutaneous leiomyomas, uterine fibroids, and renal cell carcinoma.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This report describes a unique case of HLRCC because it presented in pregnancy with development of cutaneous pilar leiomyomas.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Review of the literature for previous cases of Reed\u2019s syndrome during pregnancy including PubMed and Medline search.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Genetic testing of this patient demonstrated a mutation in the fumarate hydratase ( FH) gene. Review of the literature showed only 1 previous case series that described the onset of cutaneous lesions during pregnancy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case serves as a reminder that there may exist a correlation between pregnancy and the first manifestation of cutaneous lesions in patients with HLRCC, and thus an increased clinical suspicion is warranted during this period.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1203475416634091","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T23:26:25Z","timestamp":1456183585000},"page":"334-336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["First Presentation of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Pregnancy"],"prefix":"10.1177","volume":"20","author":[{"given":"Kathryn","family":"Woolner","sequence":"first","affiliation":[{"name":"University of Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Civic Campus, Parkdale Clinic, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"LaBerge","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Civic Campus, Parkdale Clinic, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"bibr1-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051633798"},{"key":"bibr2-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1038\/ng849"},{"key":"bibr3-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121358"},{"key":"bibr4-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1996.tb00726.x"},{"key":"bibr5-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.2.199"},{"key":"bibr6-1203475416634091","unstructured":"Pithukpakorn M, Toro JR. Hereditary leiomyomatosis and renal cell cancer. July 31, 2006 [updated August 6, 2015]. In: Pagon RA, Adam MP, Ardinger HH, eds. GeneReviews\u00ae [Internet]. Seattle, WA: University of Washington, Seattle; 1993-2015. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1252\/."},{"key":"bibr7-1203475416634091","unstructured":"Hoffman BL, Schorge JO, Schaffer JI, Chapter 9. Pelvic mass. In: Hoffman BL, Schorge JO, Schaffer JI. eds. Williams Gynecology, 2e. New York, NY: McGraw-Hill; 2012. http:\/\/accessmedicine.mhmedical.com.proxy.bib.uottawa.ca\/content.aspx?bookid=399&Sectionid=41722297. Accessed January 4, 2016."},{"key":"bibr8-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01486.x"},{"key":"bibr9-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1086\/376435"},{"key":"bibr10-1203475416634091","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9428-z"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475416634091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475416634091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475416634091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:53:27Z","timestamp":1777391607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475416634091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1177\/1203475416634091"],"URL":"https:\/\/doi.org\/10.1177\/1203475416634091","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]}}}