{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:08:53Z","timestamp":1777514933622,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T00:00:00Z","timestamp":1479340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Onychomycosis is a cosmetic and, at times, medical concern; therefore, effective and safe alternatives to treatment are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the efficacy of a 1064-nm Nd:YAG laser for the treatment of onychomycosis in a real-world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single-centre retrospective chart review was conducted between 2012 and 2013. One hundred consecutive patients with a culture- and\/or potassium hydroxide\u2013confirmed diagnosis of onychomycosis were treated at least twice. Baseline and follow-up photographs were taken, and the change in degree of clinical nail involvement of the subject\u2019s great toenail was determined by a blinded reviewer using validated planimetry measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 199 hallux nails from 100 subjects were assessed. The mean infected area decreased from 53.2% at baseline to 50.8% at the end of the study (paired t test, P = .054; Wilcoxon signed rank test, P = .006). Degree of nail involvement was statistically significantly associated with amount of improvement; subjects who had the greatest degree of nail involvement improved the most, while those with less severe disease showed a worsening of nail appearance (Kruskal-Wallis test, P &lt; .001). Three-quarters (72.6%) of nails that had more than 67% nail involvement showed statistically significant improvement (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test, P = .001). Adverse events were limited to mild to moderate pain at the time of therapy. A total of 76 subjects were assessed for treatment satisfaction: 60% were very satisfied with treatment despite limited clinical improvement in some cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Laser therapy has a very limited positive clinical effect on the appearance of onychomycosis after 2 treatment sessions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475416676804","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T20:24:15Z","timestamp":1479414255000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Real-World Efficacy of 1064-nm Nd:YAG Laser for the Treatment of Onychomycosis"],"prefix":"10.1177","volume":"21","author":[{"given":"Jason K.","family":"Rivers","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada"},{"name":"Pacific Dermaesthetics, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianne J.","family":"Vestvik","sequence":"additional","affiliation":[{"name":"Pacific Dermaesthetics, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver, BC, 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