{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:49:37Z","timestamp":1780778977101,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Primary cutaneous CD4\n                      <jats:sup>+<\/jats:sup>\n                      small\/medium T-cell lymphoproliferative disorder (CD4\n                      <jats:sup>+<\/jats:sup>\n                      PCSM-LPD) is defined by a predominance of small- to medium-sized CD4\n                      <jats:sup>+<\/jats:sup>\n                      pleomorphic T cells and a favorable clinical course.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective analysis of 6 patients with CD4\n                      <jats:sup>+<\/jats:sup>\n                      PCSM-LPD and reviewed the literature to address questions about its diagnosis, treatment, and prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients were 3 men and 3 women with a median age of 50 years. All patients presented with a single erythematous nodule, localised on the head in 4 patients and the upper trunk in 2 cases. No patients showed extracutaneous disease at any evaluation. Histopathologic features were characterised by nodular, diffuse, or, in 1 case, a superficial dense infiltrate of small\/medium-sized pleomorphic CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/PD1\n                      <jats:sup>+<\/jats:sup>\n                      T lymphocytes. T-cell receptor clonality was demonstrated in 5 cases. Treatment was surgical excision in 5 cases and radiotherapy in 1 case.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients achieved complete resolution without relapses, during a median follow-up of 3 years. A review of the literature confirmed that CD4\n                      <jats:sup>+<\/jats:sup>\n                      PCSM-LPD presents predominantly with a solitary nodular lesion on the face, neck, or upper trunk in adult patients. Surgical excision is the preferred treatment. Spontaneous resolution after biopsy may occur.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      CD4\n                      <jats:sup>+<\/jats:sup>\n                      PCSM-LPD is a rare disorder with a favorable course.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475417715209","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T10:41:38Z","timestamp":1497350498000},"page":"502-506","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Primary Cutaneous CD4\n                    <sup>+<\/sup>\n                    Small\/Medium Pleomorphic T-Cell Lymphoproliferative Disorder: A Case Series"],"prefix":"10.1177","volume":"21","author":[{"given":"Martina","family":"Maurelli","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Colato","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Diagnostics and Public Health, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gisondi","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"bibr1-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"bibr2-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050"},{"key":"bibr3-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13340"},{"key":"bibr4-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12806"},{"key":"bibr5-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12549"},{"key":"bibr6-1203475417715209","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ad.2015.02.015","volume":"106","author":"Gonz\u00e1lez Fern\u00e1ndez D","year":"2015","journal-title":"Actas Dermosifiliogr"},{"key":"bibr7-1203475417715209","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819f19bb"},{"key":"bibr8-1203475417715209","unstructured":"Swerdlow SH, Campo E, Harris NL, et al, eds. 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