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Psoriasis is treated with a number of topical and systemic therapies, including biologic drugs that directly target proinflammatory cytokines. This cross-sectional retrospective study investigated comorbid conditions reported in the Newfoundland and Labrador psoriasis population, outcomes associated with therapeutic treatment, and use of health care resources. Of the psoriasis comorbidities investigated, psoriatic arthritis was significantly associated with the use of biologic therapy while a failure to respond to biologics was associated with a higher incidence of cardiovascular disease. Patients responsive to biologic treatment had fewer hospital stays than patients treated with other therapies. Our results suggest that biologic therapies have a cardioprotective effect and reduce the number of hospital visits in patients whose symptoms are responsive to treatment.<\/jats:p>","DOI":"10.1177\/1203475418791114","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:56:05Z","timestamp":1532480165000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["An Investigation of Comorbid Disease and Health Service Utilization Among Patients With Moderate to Severe Psoriasis in Newfoundland and Labrador"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-232X","authenticated-orcid":false,"given":"Wayne P.","family":"Gulliver","sequence":"first","affiliation":[{"name":"Newlab Clinical Research, St. John\u2019s, NL, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John\u2019s, NL, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Randell","sequence":"additional","affiliation":[{"name":"Newlab Clinical Research, St. John\u2019s, NL, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Gulliver","sequence":"additional","affiliation":[{"name":"Newlab Clinical Research, St. John\u2019s, NL, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Newfoundland and Labrador Centre for Health Information, St. John\u2019s, NL, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Gregory","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Canada, Dorval, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Nagle","sequence":"additional","affiliation":[{"name":"Novartis Latin America Services, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Chambenoit","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"bibr1-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08669.x"},{"key":"bibr2-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-006-0102-2"},{"key":"bibr3-1203475418791114","author":"Canadian Psoriasis Guidelines Committee (2009)","year":"2009","journal-title":"Canadian Guidelines for the Management of Plaque Psoriasis"},{"key":"bibr4-1203475418791114","first-page":"323","volume":"64","author":"Nall L","year":"1999","journal-title":"Cutis"},{"key":"bibr5-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1185\/030079904X15192"},{"key":"bibr6-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.014"},{"key":"bibr7-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06240.x"},{"key":"bibr8-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107501"},{"key":"bibr9-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2003.09110.x"},{"key":"bibr10-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107501"},{"key":"bibr11-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08779.x"},{"key":"bibr12-1203475418791114","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.10013"},{"key":"bibr13-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1002\/art.24328"},{"key":"bibr14-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.017"},{"key":"bibr15-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0703-z"},{"key":"bibr16-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.021"},{"key":"bibr17-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10525.x"},{"key":"bibr18-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062"},{"key":"bibr19-1203475418791114","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416650430"},{"key":"bibr20-1203475418791114","unstructured":"National Psoriasis Foundation. 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